Oncology

Reports of high-impact oncology studies by medical professionals

Augmented adoptive cell transfer eradicates solid tumors [PreClinical]

  1. Combining tumor-specific T cells and pathogen-based immune stimulation, reenergized adoptive cell transfer (ReACT) targeted and eradicated tumor cells in mice. 2. ReACT led to...

Scalp cooling reduces alopecia among women undergoing chemotherapy for breast cancer

1. Less hair loss was observed in women who received scalp cooling prior to the start of adjuvant chemotherapy for early-stage breast cancer. 2. Improved...

Potential therapeutic target discovered for triple negative breast cancer [PreClinical]

1. Expression of the PIM1 protein was elevated in tumor samples from patients with MYC-positive triple negative breast cancer (TNBC), and was also associated...

Obesity leaves patients vulnerable to suboptimal end-of-life care

1. In this retrospective cohort, obesity was associated with reduced hospice use and in-home death during the last 6 months of life. 2. Higher Medicare...

Long-term users of e-cigarettes have decreased carcinogen and toxin levels compared to users of...

1. Former smokers who used only e-cigarettes or only nicotine replacement therapy (NRT) for ≥6 months (long-term) were found to have generally similar levels...

Adding antiandrogen therapy to radiation improves overall survival in recurrent prostate cancer

1. The addition of biclutamide (antiandrogen) to radiation therapy for recurrent prostate cancer improved overall survival compared to radiation alone. 2. Radiation therapy and biclutamide...

Lessons from real-world implementation of lung cancer screening

1. In this clinical demonstration project of implementing lung cancer screening for smokers in selected Veterans Health Administration hospitals, there were challenges in project...

pH-sensitive nanoparticles reduce cancer growth by deoxygenating tumor tissue [PreClinical]

1. Under mildly acidic in vitro conditions, silicon-based nanoparticles (NPs) effectively scavenged dissolved and hemoglobin-bound oxygen (O2) and reduced breast cancer cell viability.   2....

Antibody-based imaging can monitor prostate cancer progression [PreClinical]

1. In a mouse model of prostate cancer (PCa), a radiolabeled antibody (89Zr-11B6) targeting the androgen receptor (AR) pathway noninvasively detected AR-active primary and...

Radiolabeled somatostatin analogue linked with improved survival in neuroendocrine tumors

1. 177Lu-Dotatate, a radiolabeled somatostatin analogue, was associated with increased progression-free survival and decreased overall mortality compared to standard therapy in the treatment of...
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