Gastroenterology

Reports of high-impact gastroenterology studies by medical professionals

Bariatric surgery superior to medical therapy for diabetes at five-years: The STAMPEDE trial

1. Bariatric surgery significantly reduced and sustained glycated hemoglobin (HbA1c) levels compared to medical therapy at five-year follow-up. 2. Both gastric bypass and sleeve gastrectomy...

Similar clinical outcomes in mild/moderate Clostridium difficile infection with metronidazole versus vancomycin

1. In this retrospective cohort study, clinical outcomes and recurrence rates of mild to moderate Clostridium difficile infection (CDI) were similar among patients initially...

Bezlotoxumab associated with lower recurrence of C. difficile infection: The MODIFY I and II...

1. Bezlotoxumab therapy associated with significantly lower rate of recurrent C. difficile infection compared to placebo. 2. Actoxumab not efficacious when administered aloine or...

Metformin associated with reduced mortality in kidney disease, congestive heart failure, and chronic liver...

1. Metformin use is associated with reduced all-cause mortality in patients with chronic kidney disease, congestive heart failure, or chronic liver disease with hepatic...

Low volume status linked to adverse outcomes in shiga-toxin producing Eschericia coli illness

1. Based on a systematic review and meta-analysis, low volume status (as estimated with clinical judgement or hematocrit values) in children presenting with shiga-toxin...

Ustekinumab linked with efficacy in treatment of Crohn’s disease: The UNITI-1 & 2, IM-UNITI...

1. Ustekinumab achieved successful clinical induction in a greater proportion of patients with moderate to severe Crohn’s disease (CD) compared to placebo in two...

Ledipasvir-sofosbuvir may be safe treatment for kidney transplant recipients with chronic HCV

1. Ledipasvir-sofosbuvir treatment was associated with rapid chronic hepatitis C (HCV) RNA suppression. 2. Ledipasvir-sofosbuvir treatment was generally well tolerated in kidney transplant patients. Evidence Rating...

Mild-to-moderate hypertriglyceridemia associated with higher risk of acute pancreatitis

1. This prospective cohort study, conducted in Copenhagen, found that mild-to-moderate levels of non-fasting hypertriglyceridemia, from 177 mg/dL (2 mmol/L) and above, were associated...

Targeted thyroid hormone delivery reduces off-target effects [PreClinical]

1. Delivery of a hybridized form of glucagon and the thyroid hormone T3 (G/T3) improved signs of metabolic syndromes including dyslipidemia and nonalcoholic steatohepatitis...

Improving heat-shock protein levels shows efficacy against lysosomal storage diseases [PreClinical]

1. Treatment with recombinant heat-shock protein 70 (rHSP70) reduced lysosomal enlargement in cells isolated from patients with various lysosomal storage diseases (LSDs) such as...
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