Gastroenterology

Reports of high-impact gastroenterology studies by medical professionals

Metformin associated with reduced mortality in kidney disease, congestive heart failure, and chronic liver...

1. Metformin use is associated with reduced all-cause mortality in patients with chronic kidney disease, congestive heart failure, or chronic liver disease with hepatic...

Low volume status linked to adverse outcomes in shiga-toxin producing Eschericia coli illness

1. Based on a systematic review and meta-analysis, low volume status (as estimated with clinical judgement or hematocrit values) in children presenting with shiga-toxin...

Ustekinumab linked with efficacy in treatment of Crohn’s disease: The UNITI-1 & 2, IM-UNITI...

1. Ustekinumab achieved successful clinical induction in a greater proportion of patients with moderate to severe Crohn’s disease (CD) compared to placebo in two...

Ledipasvir-sofosbuvir may be safe treatment for kidney transplant recipients with chronic HCV

1. Ledipasvir-sofosbuvir treatment was associated with rapid chronic hepatitis C (HCV) RNA suppression. 2. Ledipasvir-sofosbuvir treatment was generally well tolerated in kidney transplant patients. Evidence Rating...

Mild-to-moderate hypertriglyceridemia associated with higher risk of acute pancreatitis

1. This prospective cohort study, conducted in Copenhagen, found that mild-to-moderate levels of non-fasting hypertriglyceridemia, from 177 mg/dL (2 mmol/L) and above, were associated...

Targeted thyroid hormone delivery reduces off-target effects [PreClinical]

1. Delivery of a hybridized form of glucagon and the thyroid hormone T3 (G/T3) improved signs of metabolic syndromes including dyslipidemia and nonalcoholic steatohepatitis...

Improving heat-shock protein levels shows efficacy against lysosomal storage diseases [PreClinical]

1. Treatment with recombinant heat-shock protein 70 (rHSP70) reduced lysosomal enlargement in cells isolated from patients with various lysosomal storage diseases (LSDs) such as...

Colorectal cancer prevention though screening colonoscopies may have less benefit in those older than...

1. This study estimates that the 8-year risk for colorectal cancer (CRC) in Medicare beneficiaries was reduced by screening colonoscopy from 2.6% to 2.2%...

Electroacupuncture may be an effective treatment for chronic severe functional constipation

1. Patients treated with electroacupuncture (EA) had a greater increase in complete spontaneous bowel movements (CSBM) compared to the control group (sham EA). 2. Acupuncture-related...

Current therapies ineffective at reducing epistaxis in hereditary hemorrhagic telangiectasia

1. No intranasal drug treatment (bevacizumab, estriol, or tranexamic acid) significantly reduced epistaxis duration compared to placebo. 2. There were no significant differences between these...
licensing as small