Infectious Disease

Reports of high-impact infectious disease studies by medical professionals

Recurrent Clostridium difficile infection associated with gastric acid suppression

1. In this systematic review and meta-analysis of observational data, gastric acid suppression was associated with increased risk of recurrent Clostridium difficile infection (CDI). 2....

Multiple oral direct-acting antiviral regimens associated with sustained virologic response for hepatitis C virus...

1. Multiple oral direct-acting antiviral (DAA) interferon-free therapies with high SVR rates are available for all six hepatitis C virus (HCV) genotypes. 2. These DAA...

Reduced yet persistent incidence of vertical HIV transmission in the United States

1. Overall incidence of vertical HIV transmission in the United States decreased from 2002 to 2013, and currently is at an estimated 1.75 per...

Despite guidelines, pediatricians vary in antibiotic choice for pneumonia

1. The majority of children in outpatient clinics were prescribed a macrolide antibiotic for treatment of community acquired pneumonia (CAP) despite clear guidelines recommending amoxicillin...

Similar clinical outcomes in mild/moderate Clostridium difficile infection with metronidazole versus vancomycin

1. In this retrospective cohort study, clinical outcomes and recurrence rates of mild to moderate Clostridium difficile infection (CDI) were similar among patients initially...

Recommendations for Childhood and Adolescent Immunizations

1. The American Academy of Pediatrics (AAP) has published the newest recommendations for immunization of children and adolescents. These changes include updates to the...

Bezlotoxumab associated with lower recurrence of C. difficile infection: The MODIFY I and II...

1. Bezlotoxumab therapy associated with significantly lower rate of recurrent C. difficile infection compared to placebo. 2. Actoxumab not efficacious when administered aloine or...

Recombinant vesicular stomatitis virus vaccine elicits anti-Ebola seroconversion

1. By day 28, all recipients of a recombinant vesicular stomatitis virus (rVSV) vaccine, at each of the three doses tested, demonstrated seroconversion against...

Effectiveness of meningococcal conjugate vaccine wanes after 3-8 years

1. The overall effectiveness of the meningococcal conjugate vaccine between 0 and 8 years post-vaccination was 69%. 2. The vaccine effectiveness (VE) was 79% at...

Pritelivir reduces HSV-2 positive swabs in those with multiple recurrences

1. In this randomized controlled trial, pritelivir was effective in reducing the number of HSV-2 positive swabs, total days with herpetic lesions, and the...
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