Infectious Disease

Reports of high-impact infectious disease studies by medical professionals

Similar clinical outcomes in mild/moderate Clostridium difficile infection with metronidazole versus vancomycin

1. In this retrospective cohort study, clinical outcomes and recurrence rates of mild to moderate Clostridium difficile infection (CDI) were similar among patients initially...

Recommendations for Childhood and Adolescent Immunizations

1. The American Academy of Pediatrics (AAP) has published the newest recommendations for immunization of children and adolescents. These changes include updates to the...

Bezlotoxumab associated with lower recurrence of C. difficile infection: The MODIFY I and II...

1. Bezlotoxumab therapy associated with significantly lower rate of recurrent C. difficile infection compared to placebo. 2. Actoxumab not efficacious when administered aloine or...

Recombinant vesicular stomatitis virus vaccine elicits anti-Ebola seroconversion

1. By day 28, all recipients of a recombinant vesicular stomatitis virus (rVSV) vaccine, at each of the three doses tested, demonstrated seroconversion against...

Effectiveness of meningococcal conjugate vaccine wanes after 3-8 years

1. The overall effectiveness of the meningococcal conjugate vaccine between 0 and 8 years post-vaccination was 69%. 2. The vaccine effectiveness (VE) was 79% at...

Pritelivir reduces HSV-2 positive swabs in those with multiple recurrences

1. In this randomized controlled trial, pritelivir was effective in reducing the number of HSV-2 positive swabs, total days with herpetic lesions, and the...

Shorter courses of antibiotics for otitis media less effective in children

1. Reducing the duration of antibiotic treatment for acute otitis media (AOM) in children aged 6-23 months was associated with a higher rate of...

Dry cord care non-inferior to antiseptic care

1. In this cluster-randomized, 2-period crossover trial, omphalitis occurred in 0.07% of newborns randomized to dry umbilical cord care compared to 0% in those...

Small molecule inhibitor may resolve parasitic infections of neglected tropical diseases [PreClinical]

1. In several mouse models, a novel small molecule inhibitor, GNF6702 (GNF), effectively cleared infections of parasites that cause leishmaniasis, Chagas disease (CD), and...

Adverse neurologic outcomes associated with maternal Zika virus infection

1. Infants born to symptomatic Zika-positive mothers demonstrated higher rates of fetal death, fetal growth restriction and central nervous system abnormalities. 2. Zika-positive pregnant women...
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