New treatment target for paclitaxel-induced pain [PreClinical]

1. In mouse models, the lipid metabolite 9,10 EpOME was identified as an important mediator of paclitaxel-induced peripheral neuropathic pain (PIPN). 2. Following the...

Correcting NAD+ depletion may improve muscular degeneration in Duchenne muscular dystrophy [PreClinical]

1. Dietary supplementation with nicotinamide riboside (NR), a form of vitamin B3 that acts as a precursor to nicotinamide adenine dinucleotide (NAD+), increased levels...

Antibody decreases Zika virus levels and fetal transmission [PreClinical]

1. Antibodies were isolated from patients with prior Zika virus infection and one specific antibody, ZIKV-117, decreased fetal transmission of Zika virus as well...

Stem cell transplant in primates treats injured hearts [PreClinical]

1. After undergoing a transient myocardial infarction (MI), primates injected with stem cells showed improved heart function. 2. None of the primates that received...

Combination therapy effectively treats hepatocellular carcinoma in mice [PreClinical]

  1. When combined with hepatic artery ligation, the current treatment for hepatocellular carcinoma (HCC), tirapazimine (TPZ) was found to decrease tumor recurrence in mice....

New peptide-modified hydrogel developed for diabetic wound healing [PreClinical]

1. The peptide QHREDGS protected human epithelial cells from oxidative stress and promoted cell migration and survival. 2. When a hydrogel containing this peptide was...

Blocking fatty acid synthesis may curb lung cancer growth [PreClinical]

1. ND-646, a small molecule inhibitor of FASyn, an enzyme involved in fatty acid synthesis, caused reduced growth and viability of non-small cell lung cancer...

Targeted thyroid hormone delivery reduces off-target effects [PreClinical]

1. Delivery of a hybridized form of glucagon and the thyroid hormone T3 (G/T3) improved signs of metabolic syndromes including dyslipidemia and nonalcoholic steatohepatitis...

New treatment developed for cancer-induced weight loss [PreClinical]

  1. In mouse models of cancer-induced fat and muscle wasting (cachexia), lower levels of the protein Ampk were accompanied by higher levels of the...

Improving heat-shock protein levels shows efficacy against lysosomal storage diseases [PreClinical]

1. Treatment with recombinant heat-shock protein 70 (rHSP70) reduced lysosomal enlargement in cells isolated from patients with various lysosomal storage diseases (LSDs) such as...
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