Augmented adoptive cell transfer eradicates solid tumors [PreClinical]

  1. Combining tumor-specific T cells and pathogen-based immune stimulation, reenergized adoptive cell transfer (ReACT) targeted and eradicated tumor cells in mice. 2. ReACT led to...

Inhibition of the immunoproteasome may improve graft acceptance [PreClinical]

  1. A targeted immunoproteasome inhibitor, DPLG3, was found to have high selectivity for the immune cell proteasome and was not toxic to other cell...

New probiotic treatment for obesity and diabetes [PreClinical]

1. Administering various formulations of the Akkermansia (A.) muciniphila bacterium to mice resulted in improved metabolism and decreased weight gain. 2. A. muciniphila decreased body...

Potential therapeutic target discovered for triple negative breast cancer [PreClinical]

1. Expression of the PIM1 protein was elevated in tumor samples from patients with MYC-positive triple negative breast cancer (TNBC), and was also associated...

Antibody-based imaging can monitor prostate cancer progression [PreClinical]

1. In a mouse model of prostate cancer (PCa), a radiolabeled antibody (89Zr-11B6) targeting the androgen receptor (AR) pathway noninvasively detected AR-active primary and...

Protein therapy combined with stem cell transplantation repairs stroke-induced brain damage [PreClinical]

  1. Neural stem cell (NSC) transplantation and subsequent treatment with a variant of activated protein C (3K3A-APC) improved engraftment success and motor skills in...

New treatment target for paclitaxel-induced pain [PreClinical]

1. In mouse models, the lipid metabolite 9,10 EpOME was identified as an important mediator of paclitaxel-induced peripheral neuropathic pain (PIPN). 2. Following the...

Correcting NAD+ depletion may improve muscular degeneration in Duchenne muscular dystrophy [PreClinical]

1. Dietary supplementation with nicotinamide riboside (NR), a form of vitamin B3 that acts as a precursor to nicotinamide adenine dinucleotide (NAD+), increased levels...

Small molecule inhibitor may resolve parasitic infections of neglected tropical diseases [PreClinical]

1. In several mouse models, a novel small molecule inhibitor, GNF6702 (GNF), effectively cleared infections of parasites that cause leishmaniasis, Chagas disease (CD), and...

Antibody decreases Zika virus levels and fetal transmission [PreClinical]

1. Antibodies were isolated from patients with prior Zika virus infection and one specific antibody, ZIKV-117, decreased fetal transmission of Zika virus as well...
licensing as small

Popular