Novel imaging agent could enable pulmonary fibrosis diagnosis and monitoring [PreClinical]

  1. A gallium-labeled, collagen-binding peptide (68Ga-CBP8) specifically identified fibrotic tissue via positron emission tomography (PET) imaging in two mouse models of idiopathic pulmonary fibrosis...

Glucocorticoid compounds improve stem cell transplant efficiency in mice [PreClinical]

  1. Following treatment with glucocorticoids, human hematopoietic stem cells (HSCs) from cord blood demonstrated enhanced homing and engraftment to bone marrow in mice. 2. Glucocorticoids...

Müllerian inhibiting substance is a safe contraceptive that prevents chemotherapy-induced infertility [PreClinical]

1. Müllerian inhibiting substance (MIS) was found to be a successful and safe contraceptive in female mice. 2. Female mice administered MIS during chemotherapy exhibited...

Nicotine ameliorates schizophrenia cognitive deficits in mice [PreClinical]

  1. A gene alteration in the nicotinic acetylcholine receptor (nAChR) α5 subunit, previously found to be associated with schizophrenia, was recapitulated in mice and led...

Augmented adoptive cell transfer eradicates solid tumors [PreClinical]

  1. Combining tumor-specific T cells and pathogen-based immune stimulation, reenergized adoptive cell transfer (ReACT) targeted and eradicated tumor cells in mice. 2. ReACT led to...

Inhibition of the immunoproteasome may improve graft acceptance [PreClinical]

  1. A targeted immunoproteasome inhibitor, DPLG3, was found to have high selectivity for the immune cell proteasome and was not toxic to other cell...

New probiotic treatment for obesity and diabetes [PreClinical]

1. Administering various formulations of the Akkermansia (A.) muciniphila bacterium to mice resulted in improved metabolism and decreased weight gain. 2. A. muciniphila decreased body...

Potential therapeutic target discovered for triple negative breast cancer [PreClinical]

1. Expression of the PIM1 protein was elevated in tumor samples from patients with MYC-positive triple negative breast cancer (TNBC), and was also associated...

Antibody-based imaging can monitor prostate cancer progression [PreClinical]

1. In a mouse model of prostate cancer (PCa), a radiolabeled antibody (89Zr-11B6) targeting the androgen receptor (AR) pathway noninvasively detected AR-active primary and...

Protein therapy combined with stem cell transplantation repairs stroke-induced brain damage [PreClinical]

  1. Neural stem cell (NSC) transplantation and subsequent treatment with a variant of activated protein C (3K3A-APC) improved engraftment success and motor skills in...
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