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#VisualAbstract: 3-day vs. 5-day amoxicillin treatment for chest-indrawing pneumonia in children from Malawi

...ently, the World Health Organization (WHO) recommends administering a five-day course of amoxicillin for chest-indrawing pneumonia defined as cough lasting for less than 14 days or difficulty breathing with visible indrawing of the chest wall. However, it is unclear whether a five-day course is necessary for effective treatment. As such, this study compared the efficacy of three-day amoxicillin treatment to the standard five-day amoxicillin treatm...

Three-day amoxicillin course effective for chest-indrawing pneumonia in Malawi children

...ently, the World Health Organization (WHO) recommends administering a five-day course of amoxicillin for chest-indrawing pneumonia defined as cough lasting for less than 14 days or difficulty breathing with visible indrawing of the chest wall. However, it is unclear whether a five-day course is necessary for effective treatment. As such, this study compared the efficacy of three-day amoxicillin treatment to the standard five-day amoxicillin treatm...

5-day versus 10-day course of remdesivir in patients with severe COVID-19

...controlled trials show that it may accelerate recovery from COVID-19. A 10-day course of treatment has been the standard in previous studies, but with millions of cases worldwide and the production of remdesivir proceeding at a crawl, shortening the treatment duration could reduce the length of hospital stays and increase the number of patients who can be treated with a limited drug supply. This study found that there was no significant difference...

Full-day preschool programs linked to improved overall student performance

...rovement in academic performance at the end of the school year versus part-day (3 hour) programs. 2. About 81% of full day students were at or above the national average in ≥4 metrics of development compared to 59% of part-day students. Evidence Rating Level: 2 (Good) Study Rundown: Preschool education in this country usually begins at age 3 or 4. It is often where a child is first exposed fundamentals such as the alphabet, numbers, and naming col...

[Physician Comment] Next-day discharge after planned Cesarean delivery results in equivalent patient satisfaction, no...

...ay 1 discharge= 87%, day 2=85.5%; p=0.75), as was exclusive breastfeeding (day 1=45%, day 2=45%; p=0.99). Both intention-to-treat and per-protocol analyses showed no differences in a variety of secondary outcomes, including rehospitalizations, unscheduled outpatient consultations and maternal anxiety and depression. In sum: Next-day (post-Cesarean day 1) discharge resulted in similar rates of patient satisfaction, exclusive breastfeeding and a ran...

Replacement of infusion sets every seven days may be safe and cost-effective to prevent...

...dies suggest the optimal time interval for infusion set replacement to be four days, such a duration can have both financial and logistical limitations. This randomized controlled trial aimed to compare the effectiveness and costs of 7-day (intervention) versus 4-day (control) infusion set replacement to prevent life-threatening CRBSI in patients with central venous access devices and peripheral arterial catheters. The primary outcome was CRBSI, d...

Comparative analysis of wounds from oral mucosa versus skin reveals novel therapeutic targets for...

...veral subjects received follow-up biopsies at later time points (either at day 3 or day 6). Tracking of wound diameter over time indicated that wounds in the oral mucosa healed significantly faster than skin wounds. Paired oral and skin samples were then used for gene expression (RNA-seq) analysis. These analyses revealed an overall up-regulation of gene activity in the skin wounds between day 1 and day 6, indicating that the skin wounds had not c...

Patient Basics: Subdural Hematoma

...-0500 Toll-Free: 1-888-566-2267 Fax: 847-378-0600 http://www.neurosurgerytoday.org/ Brain Injury Association of America 8201 Greensboro Drive Subdural Hematoma What Is It? A subdural hematoma occurs when a blood vessel near the surface of the brain bursts. Blood builds up between the brain and the brain’s tough outer lining. The condition is also called a subdural hemorrhage. In a subdural hematoma, blood collects immediately beneath the dura mate...

Patient Basics: Soft Tissue Sarcoma

...Grove Village, IL 60007-1098 Phone: 847-434-4000 Fax: 847-434-8000 http://www.aap.org/ American Society of Clinical Oncology 1900 Duke St., Suite 200 Alexandria, VA 22314 Phone: 703-299-0150 Fax: 703-299-1044 http://www.asco.org/ American Academy of Orthopaedic Surgeons (AAOS) 6300 North River Road Rosemont, IL 60018-4262 Phone: 847-823-7186 Toll-Free: 800-346-2267 Fax: 847-823-8125 http://orthoinfo.aaos.org/ American Academy of Otolaryngology, H...

A word on stats [Perspective]

...nt obstacle, a kind of natural static that blocked our ability to hear the law. The law of errors transformed this static from random noise into something that itself was predictable, a scrambling code that, with the key, could be decoded to reveal the underlying regularity. Error was no longer insurmountably random, and its predictability was itself a tool to help us access natural laws. [/tab] [tab] This insight has forever changed our approach...

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