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Maternal folic acid supplementation during early pregnancy associated with lower risk of autism

...m diagnosis. As the authors did not specifically record the doses of folic acid being taken, specific recommendations regarding the necessary dosage cannot be made from the results presented. Moreover, folic acid intake during the twelve week period of interest was not stratified in greater detail, preventing the authors from delineating the most critical period for supplementation. That said, their findings suggest that the early gestational peri...

Patient Basics: Gout

...organ foods such as liver, kidney and sweetbreads. High production of uric acid by the body. This can happen for unknown reasons. It can also occur in certain inherited genetic metabolic disorders, leukemia and during chemotherapy for cancer. The kidneys do not excrete enough uric acid. This can be caused by kidney disease; starvation; and alcohol use, especially binge drinking. This also can occur in people taking medications called thiazide diur...

[BMJ] Tranexamic acid reduces mortality in traumatic bleeding

...21-50%, and 0.77 (95% CI 0.68-0.87) for >50%, all in favour of tranexamic acid treatment. The study also found that tranexamic acid was associated with significant reductions in the risk of fatal and non-fatal thromboembolic events (OR 0.69; 95% CI 0.53-0.89). In sum: I n patients with traumatic bleeding, reductions in all-cause mortality and deaths from bleeding did not significantly differ according to baseline risk of mortality. By using trane...

Tranexamic acid during joint surgery may reduce need for blood transfusions

...atients undergoing total hip or knee arthroplasty in U.S. hospitals between 2006 and 2012. During this time period, perioperative use of tranexamic acid increased from nearly 0% to over 11%. Patients who received tranexamic acid had significantly lower rates of transfusion, thromboembolic complications, acute renal failure, and combined complications compared to patients not receiving tranexamic acid. Further statistical analyses showed that trane...

Early, short-term tranexamic acid does not improve clinical outcomes at 6 months in patients...

...r comparison study In-depth [randomized controlled trial]: Between July 24, 2013, and July 29, 2019, 955 patients were enrolled across eight treatment centers and 16 referring hospitals in the Netherlands. Included patients were those ≥ 18 years with signs and symptoms of subarachnoid hemorrhage, and pathological findings on non-contrast CT. Patients with ongoing treatment for deep vein thrombosis or pulmonary embolism and a history of hypercoagul...

#VisualAbstract: Obeticholic acid for the treatment of non-alcoholic steatohepatitis

...ents with NASH (stage F1-F3 fibrosis) were assigned to receive obeticholic acid 25 mg daily, obeticholic acid 10 mg daily, or placebo to assess fibrosis improvement (≥1 stage) with no worsening of NASH, and NASH resolution with no worsening of fibrosis, at 18 months. The intention-to-treat population included 931 patients with stage F2-F3 fibrosis. Researchers found that more patients in the obeticholic acid groups achieved fibrosis improvement wh...

Obeticholic acid for the treatment of non-alcoholic steatohepatitis

...ents with NASH (stage F1-F3 fibrosis) were assigned to receive obeticholic acid 25 mg daily, obeticholic acid 10 mg daily, or placebo to assess fibrosis improvement (≥1 stage) with no worsening of NASH, and NASH resolution with no worsening of fibrosis, at 18 months. The intention-to-treat population included 931 patients with stage F2-F3 fibrosis. Researchers found that more patients in the obeticholic acid groups achieved fibrosis improvement wh...

Residents of disadvantaged neighborhoods who are discharged from safety-net hospitals have high hospital readmission...

...ational study utilizing Maryland’s data during the 2015 fiscal year (1 July 2014 to 30 June 2015). They assessed two main risk factors, hospital safety-net, which was defined as the mean disadvantage (mean ADI) of the hospital’s discharged patients, as well as the area disadvantage index (ADI) of the neighborhood where the patient lives. Clinical risk factors were controlled for during the statistical analysis. The primary study outcome was the 30...

New device reduces acid exposure in gastroesophageal reflux disease

...ts in quality of life, as well as a large reduction in PPI use. Due to the link between esophageal acid damage and cancer, magnetic sphincter augmentation is a novel treatment option that could reduce long term complications of GERD in patients that had only partial response to PPIs and cannot tolerate fundoplication or other surgeries. Given the small sample size and the short follow-up time of only 3 years post-op, future studies of a larger sca...

Periconceptional folic acid for prevention of neural tube defects [Classics Series]

...mmendations for daily, periconceptional intake of at least 400mcg of folic acid in healthy women and 4mg of folic acid supplementation in women with a history of a fetal neural tube defect.” In-Depth [randomized controlled trial]: A total of 7540 Hungarian women planning pregnancy, of which 4753 went on to achieve pregnancy, were randomized to receive one tablet of a multivitamin supplement containing 800mcg of folic acid (n = 2104) or a trace ele...

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