• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Altered acylcarnitine metabolism associated with increased risk of atrial fibrillation

byJack LennonandAlex Chan
October 27, 2020
in Cardiology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. A total of 7 medium- and long-chain acylcarnitines were associated with higher risk of atrial fibrillation (AF).

2. Caffeine and acisoga were associated with increased risk of incident AF while beta carotene was associated with a lower risk.

Evidence Rating Level: 2 (Good)

Atrial fibrillation (AF) is the most common cardiac arrhythmia, being noted on 175,326 death certificates in 2018 according to the CDC. However, its pathogenesis is not fully understood and the answers may lie in metabolomics. A total of 3,770 participants of the Malmö Diet and Cancer Study had 112 baseline fasting metabolites measured to investigate metabolic pathways in the development of AF (M [SD] = 58.0 [6.0] years, 59% female). Profiling was performed using liquid chromatography-mass spectrometry. Follow-ups occurred for a median of 23.2 years and 650 (17%) AF cases were identified (incidence rate = 8.6 per 1,000 person-years) with a mean age of 60.0 years (SD = 5.4 years). Adjusting for known AF risk factors, a total of 7 medium- and long-chain acylcarnitines were found to be associated with higher risk of AF (smallest HR = 1.09, 95% CI 1.00 to 1.18, largest HR = 1.14, 95% CI 1.05 to 1.24, per 1 SD increment of acylcarnitines). Beta carotene was associated with a lower risk of incident AF (HR = 0.90, 95% CI 0.82 to 0.99) while acisoga (HR = 1.08, 95% CI 1.00 to 1.18) and caffeine (HR = 1.17, 95% CI 1.06 to 1.28) were associated with an increased risk of incident AF. Overall, this study suggests alterations in acylcarnitine metabolism among those with incident AF, independent of known AF risk factors. With these metabolic changes occurring prior to AF diagnosis, there is potential to treat and prevent this condition before AF onset.

Click to read the study in JAHA

Image: PD

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

RELATED REPORTS

#VisualAbstract: New-onset atrial fibrillation following hospitalization for pneumonia associated with increased thromboembolic risk

Magnetic resonance imaging-guided fibrosis ablation plus pulmonary vein isolation non-superior to pulmonary vein isolation alone in preventing atrial arrhythmia recurrence: The DECAAF II trial

The EAST-AFNET 4 trial: Early rhythm control therapy for atrial fibrillation [Classics Series]

Tags: atrial fibrillationcardiology
Previous Post

#VisualAbstract: Outcomes of COVID-19-related ARDS patients on extracorporeal membrane oxygenation

Next Post

#VisualAbstract: Drug-eluting stents for saphenous vein grafts associated with better outcomes than bare-metal stents

RelatedReports

#VisualAbstract: New-onset atrial fibrillation following hospitalization for pneumonia associated with increased thromboembolic risk
StudyGraphics

#VisualAbstract: New-onset atrial fibrillation following hospitalization for pneumonia associated with increased thromboembolic risk

June 28, 2022
Rivaroxaban likely reduces risk of recurrent stroke in specific subgroup of patients with embolic stroke of undetermined source
Cardiology

Magnetic resonance imaging-guided fibrosis ablation plus pulmonary vein isolation non-superior to pulmonary vein isolation alone in preventing atrial arrhythmia recurrence: The DECAAF II trial

June 22, 2022
The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]
Cardiology Classics

The EAST-AFNET 4 trial: Early rhythm control therapy for atrial fibrillation [Classics Series]

June 13, 2022
Long-term outcomes for off-pump and on-pump CABG are similar
Weekly Rewinds

2 Minute Medicine Rewind June 13, 2022 

June 20, 2022
Next Post
#VisualAbstract: Drug-eluting stents for saphenous vein grafts associated with better outcomes than bare-metal stents

#VisualAbstract: Drug-eluting stents for saphenous vein grafts associated with better outcomes than bare-metal stents

Amniotic fluid lactate associated with labor disorders

COVID-19 infection in late pregnancy associated with adverse birth outcomes

Standardized developmental screening of refugee children is recommended

Parental discomfort with English associated with higher odds of adverse childhood events

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Stereotactic body radiotherapy as a state of the art treatment option in inoperable non-small cell lung cancer [Classics Series]
  • Health system-based care associated with better treatment use and high rates of tobacco abstinence at 3 months post-discharge in hospitalized smokers
  • APOEε4 genotype may increase risk of chronic traumatic encephalopathy following repetitive head impact
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.