• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood

byJack LennonandRavi Shah, MD MBA
November 11, 2019
in Chronic Disease, Pediatrics, Psychiatry
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

Intranasal oxytocin showed no benefits for pediatric autism spectrum disorder

#VisualAbstract Transplantation with omidubicel showed faster hematopoietic recovery and fewer early complications compared to standard myeloablative umbilical cord blood graft

Exercise may enhance executive function among youth with autism spectrum disorder

1. Acetaminophen burden, as measured by cord plasma samples, was associated with increased, dose-dependent risk of childhood Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.

Evidence Rating Level: 2 (Good)

Fetal acetaminophen exposure has been found to increase risk of neurodevelopmental disorders such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). However, because many of these prior studies have depended on maternal self-reports, this prospective cohort study of 996 mother-infant dyads is the first to analyze archived cord plasma samples of three acetaminophen metabolites: unchanged acetaminophen, acetaminophen glucuronide, and 3-[N-acetyl-L-cystein-S-yl]-acetaminophen. This subset of the Boston Birth Cohort participating between 1998 and 2018 included children with physician-diagnosed ADHD (25.8%), ASD (6.6%), ADHD+ASD (4.2%), other neurodevelopmental disorders (30.5%), as well as neurotypical children (32.8%). Each plasma sample included detectable, unchanged levels of acetaminophen. The second tertile (OR 2.26, 95% CI 1.40 to 3.69) and third tertile (OR 2.86, 95% CI 1.77 to 4.67) of cord acetaminophen burden were associated with increased odds of ADHD. Similar results were found for those diagnosed with ASD, with increased odds in the second tertile (OR 2.14, 95% CI 0.93 to 5.13) and third tertile (OR 3.62, 95% CI 1.62 to 8.60). Analyses across confounders such as substance use, preterm birth, child age and sex, and maternal indication yielded consistent associations between acetaminophen burden and both ADHD (ORs 2.3 to 3.5) and ASD (ORs 1.6 to 4.1). As a study that relied on cord plasma biomarkers rather than self-reports of acetaminophen use, its findings suggest that in utero exposure to acetaminophen may be associated in a dose-dependent manner with increased odds of developing ADHD or ASD.

Click to read the study in JAMA Psychiatry

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: acetaminophenattention-deficit/hyperactivity disorderautism spectrum disorderumbilical cord
Previous Post

Effect of Continued Folic Acid Supplementation Beyond the First Trimester of Pregnancy on Cognitive Performance in the Child

Next Post

Among young adults, marijuana use increased and tobacco use decreased

RelatedReports

Quick Take: Association of Prenatal Exposure to Air Pollution with Autism Spectrum Disorder
Chronic Disease

Intranasal oxytocin showed no benefits for pediatric autism spectrum disorder

November 8, 2021
#VisualAbstract Transplantation with omidubicel showed faster hematopoietic recovery and fewer early complications compared to standard myeloablative umbilical cord blood graft
StudyGraphics

#VisualAbstract Transplantation with omidubicel showed faster hematopoietic recovery and fewer early complications compared to standard myeloablative umbilical cord blood graft

October 28, 2021
Quick Take: Association of Prenatal Exposure to Air Pollution with Autism Spectrum Disorder
Pediatrics

Exercise may enhance executive function among youth with autism spectrum disorder

October 4, 2021
Adolescents’ muscle strength associated with lower cardiometabolic risk
Wellness

Wellness Check: Exercise

September 30, 2021
Next Post
Parental cannabis use increasing, cigarette use decreasing

Among young adults, marijuana use increased and tobacco use decreased

High schoolers use e-cigarettes to vaporize cannabis

2 Minute Medicine Rewind November 11, 2019

Selective Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Severe actinic keratosis and need for additional treatment are markers for an increased risk of cutaneous squamous cell carcinoma
  • Virtual yoga and meditation intervention may be associated with increased health-related quality of life
  • Wellness Check: Mental Health
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.