Oncology

Reports of high-impact oncology studies by medical professionals

[THE LANCET] Radiation exposure from CT scans in childhood linked with leukemia and brain...

Image: CC/rosiescancerfund Computed tomography (CT) imaging is a quick and easily accessible diagnostic tool, and its use has increased over the past decade. Compared to...

[NEJM] No difference in survival between intermittent androgen deprivation therapy and continuous therapy for...

Image: CC/EAS. Human PSA.  Primer: Androgen deprivation therapy is the cornerstone for metastatic prostate disease. Intermittent therapy, essentially cycles of androgen deprivation followed by exposure...

[JAMA] Risk of malignancies in patients with rheumatoid arthritis treated with biologic therapy: a...

Image: CC/Martin Steinhoff. Arthritis of the interphalangeal joints. Primer: In certain rheumatoid arthritis (RA) patients, treatment with typical disease-modifying anti-rheumatic drugs (DMARDs), including methotrexate, may...

[BMJ] Young women with BRCA1/2 mutations exposed to diagnostic radiation have higher risk of...

Image: PD. Chest x-ray.  Primer: We know that BRCA1/2 are involved in the repair of double-strand breaks. About one in 400 women have the mutation...

[CANCER] Marijuana associated with increased risk of germ cell and nonseminoma testicular cancer

Image:CC Primer: The onset of testicular germ cell tumors (TGCTs) typically occurs during puberty, and various studies have implicated changes in steroid hormones as culprits...

[Ann Intern Med.] Asymptomatic, low risk women should not be screened for ovarian cancer...

Image: CC/James Heilman. Ovarian cancer on CT scan.  Primer: Ovarian cancer, while uncommon, is the most lethal gynecologic malignancy. In 2004, the U.S. Preventive Services...

Four different types of breast cancer revealed based on molecular data

Image: CC Key study points: 1.     This study identifies four distinct types of breast cancer by integrating six different types of molecular data from breast cancer...

Enzalutamide increases survival in metastatic castration-resistant prostate cancer

Image: CC Key study points: 1.      Signaling through the androgen receptor plays a key role in the progression of prostate cancer including “castration-resistant” prostate cancer 2.      Enzalutamide,...

Trastuzumab emtansine prolongs disease-free survival in HER2-positive breast cancer

Image: CC Key findings: 1.       Trastuzumab emtansine (T-DM1), an antibody-drug conjugate, prolonged disease-free survival compared to lapatinib plus capecitabine in HER2-positive breast cancer. 2.       T-DM1 had less...

HPV vaccine associated with minimal adverse effects

Image: CC/VNU CNS Key study points: 1. The quadrivalent HPV vaccine is associated with an increased risk of same-day syncope and injection site reactions in the...
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