Oncology

Reports of high-impact oncology studies by medical professionals

Fibulin-3 shows promise as a new biomarker for pleural mesothelioma

Image: CC Key study points:  Plasma and pleural effusion levels of Fibulin-3 were significantly higher in patients with mesothelioma compared to people exposed to asbestos and...

Combined BRAF and MEK inhibition in metastatic melanoma significantly improves progression free survival

Image: CC Key study points: Approximately half of all patients with advanced melanoma have an activating BRAF mutation, which has been shown to be responsive to...

High upstage rate among nonmalignant papillary breast lesions diagnosed by image-guided core needle biopsy

Image: CC Key study points: 1.      11% of nonmalignant papillary breast lesions diagnosed by CNB were subsequently found to be malignant. 2.      Upstaging was more likely in...

HPV vaccine associated with minimal adverse effects

Image: CC/VNU CNS Key study points: 1. The quadrivalent HPV vaccine is associated with an increased risk of same-day syncope and injection site reactions in the...

Trastuzumab emtansine prolongs disease-free survival in HER2-positive breast cancer

Image: CC Key findings: 1.       Trastuzumab emtansine (T-DM1), an antibody-drug conjugate, prolonged disease-free survival compared to lapatinib plus capecitabine in HER2-positive breast cancer. 2.       T-DM1 had less...

Enzalutamide increases survival in metastatic castration-resistant prostate cancer

Image: CC Key study points: 1.      Signaling through the androgen receptor plays a key role in the progression of prostate cancer including “castration-resistant” prostate cancer 2.      Enzalutamide,...

Four different types of breast cancer revealed based on molecular data

Image: CC Key study points: 1.     This study identifies four distinct types of breast cancer by integrating six different types of molecular data from breast cancer...

[Ann Intern Med.] Asymptomatic, low risk women should not be screened for ovarian cancer...

Image: CC/James Heilman. Ovarian cancer on CT scan.  Primer: Ovarian cancer, while uncommon, is the most lethal gynecologic malignancy. In 2004, the U.S. Preventive Services...

[CANCER] Marijuana associated with increased risk of germ cell and nonseminoma testicular cancer

Image:CC Primer: The onset of testicular germ cell tumors (TGCTs) typically occurs during puberty, and various studies have implicated changes in steroid hormones as culprits...

[BMJ] Young women with BRCA1/2 mutations exposed to diagnostic radiation have higher risk of...

Image: PD. Chest x-ray.  Primer: We know that BRCA1/2 are involved in the repair of double-strand breaks. About one in 400 women have the mutation...
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