Updated review confirms efficacy and safety of most standard treatments for latent tuberculosis infection

1. Results of a meta-analysis confirm evidence of efficacy and safety of 6-month isoniazid monotherapy and rifampicin monotherapy for latent tuberculosis infection treatment. 2. Combination...

Rising price of health services drove increase in US health care spending

1. This ecological study found that between 1996-2013, annual US health care spending was largely related to increases in health care service price and...

Greater rates of mortality linked to infants at risk for maltreatment

Infants classified as very high risk for substantiated maltreatment had a higher relative risk of overall mortality, death through unintentional and inflicted injury, and...

Significant variation in mortality trends in substance use disorders among US counties

1. Mortality rates decreased for alcohol use disorders, self-harm, and interpersonal violence between 1980 and 2014. 2. Mortality rates for drug use disorders increased both...

Budesonide-formoterol as needed superior to terbutaline in mild asthma: The SYGMA trial

1. In patients with mild asthma, use of the inhaled combined corticosteroid (ICS) and beta agonist budesonide-formoterol as needed was superior to terbutaline as...

Acetaminophen reduces recurrence of febrile seizures in children within same fever episode

1. Rectal acetaminophen reduces rates of second febrile seizure (FS) in children during the course of the same febrile illness when given rectally soon...

Peripheral perfusion-targeted resuscitation does not lower mortality in septic shock patients

1. In this randomized controlled trial, there was no difference in 28-day mortality in patients with early septic shock between peripheral perfusion-targeted resuscitation and...

Quick Take: Prevalence of aspirin use for primary prevention of cardiovascular disease in the...

Aspirin (ASA) continues to be used for the primary prevention of cardiovascular disease (CVD) in patients at increased risk, despite evidence consistently demonstrating little...

39·0°C versus 38·5°C ear temperature as fever limit in children with neutropenia undergoing chemotherapy...

1. In children with neutropenia and chemotherapy for cancer, 39·0°C ear temperature as a threshold for fever is non-inferior to 38·5°C for safety and...

Lower doses of ketamine shown to be non-inferior for acute pain control in the...

1. For the treatment of acute pain in the emergency setting, 0.15 mg/kg IV ketamine was shown to be non-inferior to a higher dose...

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