Quick Take: Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children...

Convulsive status epilepticus (SE) is the most common life-threatening neurological emergency in pediatrics. It is associated with significant morbidity and mortality, with 22% of...

Metoprolol not effective in preventing exacerbations of chronic obstructive pulmonary disease

1. In this double-blind randomized trial of COPD patients without previous indication for beta blocker therapy, treatment with extended-release beta-blockers failed to generate improved...

Early changes over time in the Radiographic Assessment of Lung Edema (RALE) Score are...

1. Among patients with ARDS, a reduction in RALE score in the first three days following onset was associated with decreased mortality at 90-days. Evidence...

Azithromycin does not reduce mortality in patients hospitalized with COVID-19

1. All-cause mortality at 28 days was similar between patients in the azithromycin group and usual care alone group. 2. There was no significant difference...

Multisystem inflammatory syndrome in children remains a rare but serious complication associated with SARS-CoV-2...

1. In this cohort study, multisystem inflammatory syndrome in children was a rare but serious complication associated with SARS-CoV-2 infection. 2. The findings of increased...

Use of in vitro fertilization, twin pregnancies and advanced maternal age independently associated with...

1. The relative risk of a twin pregnancy amongst women who had undergone in vitro fertilization (IVF) compared with those who had not was...

Rate of occult fracture evaluations for child abuse insufficient

1. Less than half of children (48%) under age 2 who presented to a hospital with concern for physical abuse or non-accidental injury had underwent...

Children with persistent post-concussion symptoms have a lower quality of life

1. Based on a prospective, multicenter cohort study conducted in Canada, children after a concussion who had persistent post-concussion symptoms scored lower on a...

Small and very small unruptured intracranial aneurysms may have little risk for rupture

1. Poor-quality evidence suggests unruptured intracranial aneurysms have low growth and rupture rates. 2. Very small unruptured intracranial aneurysms are associated with little or no...

Tool may help accurately predict 30-day mortality for emergency department patients with acute heart...

1. Based on 13 independent risk factors that are available at most emergency department (ED) admissions, the MEESSI-AHF (Multiple Estimation of risk based on...

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