Endocrinology

Reports of high-impact endocrinology studies by medical professionals

Further evidence of link between antithyroid drugs in pregnancy and birth defects

Image: CC/Wiki  1. Both methimazole(MMI)/carbimazole (CMZ) and prophylthiouracil (PTU) were associated with birth defects, with differing presentations.  2. Further studies are needed to establish the specific...

Nab-paclitaxel plus gemcitabine improves survival in metastatic pancreatic cancer

Image: PD  1. Nab-paclitaxel plus gemcitabine improved overall survival, progression-free survival, and response rate compared to gemcitabine alone in advanced pancreatic cancer.  2. Combination therapy was...

High cumulative-dose isotretinoin treatment decreases risk of acne relapse

Image: PD 1. Patients receiving 220 mg/kg or more of oral isotretinoin had a significantly decreased risk of acne relapse at 1 year after treatment...

2 Minute Medicine Rewind October 28 – November 3, 2013

Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Non-publication of large randomized...

Higher BMI in girls correlated with early pubertal development

Image: PD  1. Girls with a body mass index (BMI) > 50th percentile were noted to have earlier age of onset for breast development when...

Low brown fat may explain increased susceptibility to type 2 diabetes in south Asians

Image: PD  1. Brown adipose tissue (BAT) volume, as measured by 18F-FDG uptake after cooling, was significantly higher in Caucasian than south Asian participants.  2. Resting...

Text messaging program for diabetes shows improved medication adherence

Image: PD 1. The TExT-MED program did not result in a statistically significant improvement in HbA1c levels. 2. The program was associated with trends toward improvement...

2 Minute Medicine Rewind November 11-17, 2013

Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Combined Angiotensin Inhibition for...

Hypercortisolism of bilateral macronodular adrenal hyperplasia may be corticotropin-dependent

Image: PD  1. Messenger RNA encoding proopiomelanocortin, a corticotropin precursor, was detected in all samples of hyperplastic adrenal tissue.  2. In two patients, corticotropin concentration was...

ARMC5 mutation identified in patients with macronodular adrenal hyperplasia

Image: PD  1. 55% of tumors from patients with macronodular adrenal hyperplasia possessed mutations in ARMC5, suggesting a common genetic cause of this condition.  2. AMRC5...

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