Further evidence of link between antithyroid drugs in pregnancy and birth defects
Image: CC/Wiki
1. Both methimazole(MMI)/carbimazole (CMZ) and prophylthiouracil (PTU) were associated with birth defects, with differing presentations.
2. Further studies are needed to establish the specific...
Nab-paclitaxel plus gemcitabine improves survival in metastatic pancreatic cancer
Image: PD
1. Nab-paclitaxel plus gemcitabine improved overall survival, progression-free survival, and response rate compared to gemcitabine alone in advanced pancreatic cancer.
2. Combination therapy was...
High cumulative-dose isotretinoin treatment decreases risk of acne relapse
Image: PD
1. Patients receiving 220 mg/kg or more of oral isotretinoin had a significantly decreased risk of acne relapse at 1 year after treatment...
2 Minute Medicine Rewind October 28 – November 3, 2013
Image: PD
In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week.
Non-publication of large randomized...
Higher BMI in girls correlated with early pubertal development
Image: PD
1. Girls with a body mass index (BMI) > 50th percentile were noted to have earlier age of onset for breast development when...
Low brown fat may explain increased susceptibility to type 2 diabetes in south Asians
Image: PD
1. Brown adipose tissue (BAT) volume, as measured by 18F-FDG uptake after cooling, was significantly higher in Caucasian than south Asian participants.
2. Resting...
Text messaging program for diabetes shows improved medication adherence
Image: PD
1. The TExT-MED program did not result in a statistically significant improvement in HbA1c levels.
2. The program was associated with trends toward improvement...
2 Minute Medicine Rewind November 11-17, 2013
Image: PD
In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week.
Combined Angiotensin Inhibition for...
Hypercortisolism of bilateral macronodular adrenal hyperplasia may be corticotropin-dependent
Image: PD
1. Messenger RNA encoding proopiomelanocortin, a corticotropin precursor, was detected in all samples of hyperplastic adrenal tissue.
2. In two patients, corticotropin concentration was...
ARMC5 mutation identified in patients with macronodular adrenal hyperplasia
Image: PD
1. 55% of tumors from patients with macronodular adrenal hyperplasia possessed mutations in ARMC5, suggesting a common genetic cause of this condition.
2. AMRC5...
