Pegcetacoplan improved hemoglobin levels in eculizumab-treated paroxysmal nocturnal hemoglobinuria patients

1. Pegcetacoplan was shown to reduce the change in hemoglobin level for the treatment of paroxysmal nocturnal hemoglobinuria compared to eculizumab. 2. Patients treated with...

Sutimlimab improved hemoglobin and patient symptoms in cold agglutinin disease

1. Sutimlimab was shown to stop hemolysis, improve hemoglobin levels, and reduce patient fatigue in patients with cold agglutinin disease. 2, Infections and gastrointestinal adverse...

Poloxamer 188 not effective for acute management of vaso-occlusive episodes in patients with sickle...

1. Poloxamer 188 did not decrease parenteral opioids reliance for pain control during acute vaso-occlusive episodes in adults and children with sickle cell disease. Evidence...

Aspirin treatment without indication in patients on direct oral anticoagulants may increase the risk...

1. In patients treated with direct oral anticoagulants (DOACs) for atrial fibrillation or venous thromboembolism (VTE), adding aspirin (ASA) was associated with increased bleeding...

Calcitonin-gene related peptide Antagonist Therapy Associated with Microvascular Complications in Patients with Raynaud’s Phenomenon

1. Microvascular complications were uncommon but nevertheless observed when individuals with Raynaud’s phenomenon (RP) or scleroderma were treated with Calcitonin-gene related peptide (CGRP) antagonist...

Tailored antiplatelet therapy improves outcomes in patients undergoing percutaneous coronary intervention

1. Guided selection of antiplatelet therapy reduced rates of major adverse cardiovascular event rates compared to standard therapy. 2. Guided selection strategy was beneficial for...

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