[BMJ] Young women with BRCA1/2 mutations exposed to diagnostic radiation have higher risk of...

Image: PD. Chest x-ray.  Primer: We know that BRCA1/2 are involved in the repair of double-strand breaks. About one in 400 women have the mutation...

[JAMA] Risk of malignancies in patients with rheumatoid arthritis treated with biologic therapy: a...

Image: CC/Martin Steinhoff. Arthritis of the interphalangeal joints. Primer: In certain rheumatoid arthritis (RA) patients, treatment with typical disease-modifying anti-rheumatic drugs (DMARDs), including methotrexate, may...

[NEJM] No difference in survival between intermittent androgen deprivation therapy and continuous therapy for...

Image: CC/EAS. Human PSA.  Primer: Androgen deprivation therapy is the cornerstone for metastatic prostate disease. Intermittent therapy, essentially cycles of androgen deprivation followed by exposure...

[Ann Emerg Med.] Modified Sgarbossa rule associated with improved diagnostic utility for STEMIs

Image: Sgarbossa's rules. Courtesy of EMS12lead.com Primer:  In patients presenting with an acute ST Elevated Myocardial Infarction (STEMI) in the presence of a Left Bundle...

[BMJ] Kidney stones associated with increased risk of end-stage renal disease

Image: CC/James Heilman. Stone in kidney (arrow), CT scan.  Primer: Kidney stones are a commonly encountered clinical problem, and while there is limited evidence linking...

[THE LANCET] Severe chronic kidney disease patients have higher coronary risk than diabetics. Time...

Image: CC/PD. Enlarged kidney (drawing).  Primer: Coronary heart disease (CHD) “equivalent”, a term used to describe some trait or factor that results in a 10-year risk...

[Ann Emerg Med.] False-negative FAST examination: associations with patient outcomes

Image: CC/ Positive FAST - fluid (black stripe, arrows) in Morison's pouch. Primer: The Focused Assessment with Sonography in Trauma (FAST) exam is a critical...

[Arch Intern Med.] Common environmental exposure linked to cardiovascular disease

Image: CC.  Primer: Recent evidence suggests the typical risk factors – smoking, obesity, and genetics – in cardiovascular disease (CVD) leave a portion of cases...

[JAMA] Association of changes in clinical characteristics and management with improvement in survival among...

Image: CC/GFDL. ST segment elevation in Leads II, III and aVF for an inferior acute myocardial infarction Primer: Over the past decade we have seen decreases...

[NEJM] Tiotropium a significant boost for poorly controlled asthmatics on inhaled glucocorticoids and beta-agonists

Image: Tiotropium - CC/BenWeber. Trial info: Supported by Boehringer Ingelheim and Pfizer. ClinicalTrials.gov numbers, NCT00772538 and NCT00776984. Primer: Exacerbations in asthmatics may persist despite treatment with...
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