Birinapant shows efficacy in clearing hepatitis B infection [PreClinical]

1. The small molecule drug birinapant promoted elimination of hepatitis B virus (HBV) in a mouse model of chronic infection. 2. Combination therapy with...

Vaccines for predicted influenza strains may provide wide protection [PreClinical]

1. Following infection with one influenza strain, antibodies produced in unvaccinated patients were effective against the strain as well as for a broad range...

Bevacizumab may aid tuberculosis therapy [PreClinical]

1. Tuberculosis (TB) granulomas exhibited similar properties to solid cancerous tumors, characterized as dense tissue masses with abnormal blood vessel distribution, which is thought...

LSD1 inhibition reduces herpesvirus infection and recurrence in animals [PreClinical]

1. Pharmaceutical inhibition of lysine-specific demethylase 1 (LSD1) reduced primary infection of herpes simplex virus (HSV), shedding, and reactivation in multiple animal models. 2. Inhibition...

Novel compound may correct pathological airway mucus in cystic fibrosis [PreClinical]

1. Mucus from cystic fibrosis patients had a rope-like structure and high elasticity due to chemical cross-links between mucin proteins. 2. A compound designed to...

Gut bacteria respond to daily rhythms and influence weight control

1. The daily rhythmic fluctuations of intestinal bacterial populations in both mice and humans were disrupted by changes in sleep, and in some cases,...

Genetically engineered lymphocytes inhibit Hepatitis C virus replication in vitro [PreClinical]

1. Activated suicide gene modified lymphocytes (SGMLs) inhibit Hepatitis C virus (HCV) replication multiple in vitro models of infection. 2. At low effector:target cell ratios,...

Tumor-specific mutant antigens are potential targets for cancer therapy [PreClinical]

1. Following checkpoint blockade therapy (CBT) in a mouse sarcoma model, two dominant tumor-specific mutant antigen (TSMA) targets of CD8+ T cells were identified...

Endostatin directly binds androgen receptors to treat prostate cancer [PreClinical]

1. Endostatin (ES), a drug commonly studied and applied for its inhibition of tumor blood vessel growth (termed angiogenesis), decreased proliferation of androgen-receptor (AR)...

Engineered stem cells mitigate liver damage caused by radiation [PreClinical]

1. Adipose derived stem cells (ADSCs), transfected to overexpress hepatic growth factor (HGF) or to silence HGF expression, were injected into irradiated rats to...

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