Gut bacteria respond to daily rhythms and influence weight control

1. The daily rhythmic fluctuations of intestinal bacterial populations in both mice and humans were disrupted by changes in sleep, and in some cases,...
PD

Inhibition of key enzymes in the animal brain reduces drug relapse behavior

1. A rat drug-relapse model of cocaine, heroin or nicotine addicted animals showed elevated activity of two specific enzymes, matrix metalloproteinase 2 (MMP-2) and...

Cholesterol-containing lipid particles protect mice from lethal bacterial toxins

1. Liposomes, small spheres composed of lipids, were engineered to contain artificially high cholesterol (Chol) concentrations to promote preferential binding of bacterial toxins to...

Rapamycin inhibits intestinal tumor formation and growth [PreClinical]

1. Rapamycin (rapa) inhibited tumor initiation in Adenomatous polyposis coli gene (Apc)-deficient mouse intestinal epithelial cells, and enhanced survival in a mouse intestinal tumorigenesis...

Genetically engineered lymphocytes inhibit Hepatitis C virus replication in vitro [PreClinical]

1. Activated suicide gene modified lymphocytes (SGMLs) inhibit Hepatitis C virus (HCV) replication multiple in vitro models of infection. 2. At low effector:target cell ratios,...

Vaccines for predicted influenza strains may provide wide protection [PreClinical]

1. Following infection with one influenza strain, antibodies produced in unvaccinated patients were effective against the strain as well as for a broad range...

Nanoparticles may reduce impact of neurological injury [PreClinical]

1. Squalenoyl adenosine nanoassemblies (SQAdNAs) formed by conjugating squalene, a lipid, to adenosine, a widely regarded potential neuroprotective agent, resulted in delayed metabolism of...

Tumor-specific mutant antigens are potential targets for cancer therapy [PreClinical]

1. Following checkpoint blockade therapy (CBT) in a mouse sarcoma model, two dominant tumor-specific mutant antigen (TSMA) targets of CD8+ T cells were identified...

LSD1 inhibition reduces herpesvirus infection and recurrence in animals [PreClinical]

1. Pharmaceutical inhibition of lysine-specific demethylase 1 (LSD1) reduced primary infection of herpes simplex virus (HSV), shedding, and reactivation in multiple animal models. 2. Inhibition...

Injectable loaded microparticle scaffolds improve vaccine responses in mice [PreClinical]

1. When injected into mice, long, thin mesoporous silica rods (MSRs) spontaneously formed scaffolds that recruited large numbers of cells to the empty spaces...

All-time hits