Nanoparticles may reduce impact of neurological injury [PreClinical]

1. Squalenoyl adenosine nanoassemblies (SQAdNAs) formed by conjugating squalene, a lipid, to adenosine, a widely regarded potential neuroprotective agent, resulted in delayed metabolism of...

Vaccines for predicted influenza strains may provide wide protection [PreClinical]

1. Following infection with one influenza strain, antibodies produced in unvaccinated patients were effective against the strain as well as for a broad range...

Genetically engineered lymphocytes inhibit Hepatitis C virus replication in vitro [PreClinical]

1. Activated suicide gene modified lymphocytes (SGMLs) inhibit Hepatitis C virus (HCV) replication multiple in vitro models of infection. 2. At low effector:target cell ratios,...

Rapamycin inhibits intestinal tumor formation and growth [PreClinical]

1. Rapamycin (rapa) inhibited tumor initiation in Adenomatous polyposis coli gene (Apc)-deficient mouse intestinal epithelial cells, and enhanced survival in a mouse intestinal tumorigenesis...

Cholesterol-containing lipid particles protect mice from lethal bacterial toxins

1. Liposomes, small spheres composed of lipids, were engineered to contain artificially high cholesterol (Chol) concentrations to promote preferential binding of bacterial toxins to...
PD

Inhibition of key enzymes in the animal brain reduces drug relapse behavior

1. A rat drug-relapse model of cocaine, heroin or nicotine addicted animals showed elevated activity of two specific enzymes, matrix metalloproteinase 2 (MMP-2) and...

Gut bacteria respond to daily rhythms and influence weight control

1. The daily rhythmic fluctuations of intestinal bacterial populations in both mice and humans were disrupted by changes in sleep, and in some cases,...

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