The Classics

Physician-written reports of landmark studies in medicine

Classics Series, Landmark Trials in Medicine

The SAFE trial: Normal saline vs. albumin for fluid resuscitation [Classics Series]

1. There was no significant difference in 28-day mortality when comparing albumin and normal saline for fluid resuscitation in the intensive care setting.2. Compared...
Classics Series, Landmark Trials in Medicine

The ROCKET AF: Rivaroxaban in atrial fibrillation [Classics Series]

1. Rivaroxaban is non-inferior to warfarin in preventing strokes and systemic embolism.2. Although there is no significant difference between the two in the incidence...
Classics Series, Landmark Trials in Medicine

The CURE trial: Clopidogrel in ACS without ST-elevation [Classics Series]

1. The addition of clopidogrel significantly reduced the risk of death from cardiovascular causes, nonfatal myocardial infarction, or other ischemic events in patients with...
Classics Series, Landmark Trials in Medicine

The JUPITER: Rosuvastatin in healthy patients with elevated CRP levels [Classics Series]

1. In patients with average LDL cholesterol levels and elevated CRP, rosuvastatin significantly reduced the risk of a first major cardiovascular event compared to...
Classics Series, Landmark Trials in Medicine

The HOPE trial: Ramipril significantly reduces cardiovascular events in high-risk patients with normal ejection...

Image: CC/L. academia1. Ramipril significantly reduces cardiovascular events including MI, stroke and death in high risk-patients in the absence of left ventricular dysfunctionOriginal Date...
Classics Series, Landmark Trials in Medicine

The RACE-II trial: Lenient vs. strict rate-control in atrial fibrillation [Classics Series]

1. Lenient rate-control was found to be non-inferior to strict rate-control in managing patients with atrial fibrillation.2. Compared to strict rate-control, lenient rate-control could...
Classics Series, Landmark Trials in Medicine

The TRICC trial: Restrictive transfusion in intensive care does not increase mortality [Classics Series]

1. Using a restrictive transfusion strategy in critically ill patients did not significantly increase 30-day mortality when compared with a liberal transfusion strategy.2. Subgroup...
Classics Series, Landmark Trials in Medicine

The ACCORD trial: Intensive glucose control associated with increased mortality [Classics Series]

1. Previous studies suggest that intensive blood glucose control reduces the risk of microvascular complications, though questions remained regarding the impact on macrovascular complications...
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