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Mood disorders and outcomes of COVID-19 hospitalizations
1. Mood disorder diagnoses prior to hospitalization for COVID-19 was associated with increased risk of in-hospital mortality after Day 12.
2. Prior mood disorders were associated with a greater likelihood of discharge to a lower level of care, rather than home.
Evidence Rating Level: 2 (Good)
Extrapulmonary manifestations of COVID-19 have been a major area of study over the past year, particularly as they relate to morbidity and mortality. This retrospective cohort study of six hospitals in Massachusetts sought to investigate the association between prior mood disorders and hospital outcomes among those hospitalized for COVID-19 between February 15 and May 24, 2020. A total of 2,988 individuals were hospitalized for COVID-19 during this time frame, 24% of which had a prior mood disorder diagnosis. After adjusting for age, sex, and hospital, having a mood disorder prior to hospitalization was associated with greater in-hospital mortality risk after Day 12 (crude HR = 2.156, 95% CI 1.540 to 3.020; adjusted HR = 1.540, 95% CI 1.054 to 2.250). Any mood disorder diagnosis was also associated with a greater likelihood of discharge to a lower level of care rather than home, such as a rehabilitation facility (adjusted OR = 1.504, 95% CI 1.132 to 1.999). Overall, this study suggests that mood disorders confer risks in the context of hospitalization for COVID-19, including increased mortality after Day 12 and discharge to lower levels of care, rather than home.
Click to read the study in AJP
Image: PD
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