• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

No difference in live birth rates between intracytoplasmic sperm injection and conventional in-vitro fertilization for couples with non-male factor infertility

byAlice WangandTeddy Guo
May 6, 2021
in Chronic Disease, Endocrinology, Obstetrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. For couples with a male partner with normal sperm counts and motility, intracytoplasmic sperm injection did not result in higher rates of live birth compared with conventional in-vitro fertilization (IVF).

2. Higher rates of fertilization per oocyte retrieved and per oocyte inseminated observed in intracytoplasmic injection group with no impact on outcomes at 12 months post-randomization.

 Evidence Rating Level: 1 (Excellent)

Study Rundown: Intracytoplasmic sperm injection (ICSI) is an IVF technique initially utilized in couples with severe male factor infertility. Recently, ICSI rates have increased relative to rates of conventional IVF despite retrospective studies showing similar outcomes. Additionally, use of ICSI has increased among couples with non-male factor infertility. This open-label, multicenter, randomized control trial assessed the success of ICSI compared to conventional IVF as measured by live birth in couples with a male partner who has normal sperm counts and motility. Data from this trial demonstrate comparable rates of live birth after first embryo transfer and fertilization failure among the ICSI and conventional IVF groups. The results of this study challenge the rising trend in broad ICSI use in couples without male factor infertility. Cost and invasiveness ICSI compared to conventional techniques are additional factors for couples to consider when choosing the appropriate IVF technique.

Click to read the study in The Lancet

 Relevant Reading: Predicting the chances of a live birth after one or more complete cycles of in vitro fertilisation: population based study of linked cycle data from 113 873 women 

In-Depth [randomized control trial]: This study randomized 1064 couples equally to ICSI (n=532) and conventional IVF (n=532) groups using variable block size randomization. Inclusion criteria included semen samples with normal count, motility, and morphology per WHO 2010 criteria, two or fewer prior IVF/ICSI cycles, and were not using frozen samples. Clinicians performing embryo transfer were blinded to group assignment, but patients and treating physicians were knowledgeable of group assignment. Primary outcome was defined as live birth (delivery of one baby showing any signs of life after 24 weeks gestation) after the first embryo transfer from the initiated cycle. Secondary outcomes included fertilization per oocyte inseminated or injected, abnormal oocytes, and pregnancy complication rates. At 12 months after random allocation from the initiated cycle, live birth outcomes after first embryo transfer were comparable among ICSI and conventional IVF groups (RR 1.11, 95% CI [-2.4 – 9.2], p = 0.27). Rates of fertilization per oocyte inseminated were significantly higher in the ICSI group (95% CI [2.2 – 8.6%], p = <0.0001) with lower rates of abnormal fertilization per oocyte as well (95% CI [-7.6 – -5.1%], p = <0.0001). This study is limited by a sizeable amount of patient crossover due to preference for ICSI, as well as difference in cost between the two treatment protocols, to which patients were not blinded. Despite these limitations, the results of this study challenge the use of ICSI in couples without male-factor infertility, especially with regard to resource utilization.

RELATED REPORTS

Double embryo transfer may be associated with neonatal risks

The 2 Minute Medicine Podcast Episode 3

The Scan by 2 Minute Medicine®: the New Cost of Insulin, Beyond IVF, the Spotlight on RSV and Influenza, and Theranos Founder Sentenced to 11 Years!

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: Female Infertilityfertilityfertility therapyICSIin vitro fertilizationin-vitro fertilization (IVF)infertilityintracytoplasmic sperm injectionintracytoplasmic sperm injection (ICSI)IVFnon-male infertility
Previous Post

Substance use among hospitalized adolescents infrequently documented in electronic health record

Next Post

Diagnosis of atopic dermatitis in children may be associated with lower educational attainment

RelatedReports

Assisted conception not associated with increased pediatric cancer risk
Endocrinology

Double embryo transfer may be associated with neonatal risks

December 19, 2022
2MM Podcast

The 2 Minute Medicine Podcast Episode 3

December 1, 2022
The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: the New Cost of Insulin, Beyond IVF, the Spotlight on RSV and Influenza, and Theranos Founder Sentenced to 11 Years!

November 30, 2022
Maternal vaccination during pregnancy not associated with infant hospitalization, mortality
Chronic Disease

Increased infertility rates found amongst female physicians compared to general population

November 10, 2022
Next Post
Preterm birth associated with lower high school academic performance

Diagnosis of atopic dermatitis in children may be associated with lower educational attainment

Masks for personal protection for SARS-CoV-2 infection

Infectivity of SARS-CoV-2 in children compared with adults

Pregnancy associated with postpartum vascular changes

Discontinuation of oxytocin during active labour may reduce fetal heart rate abnormalities

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Efanesoctocog alfa is efficacious in treating severe hemophilia A
  • Mavacamten associated with improvement in submaximal exertional tolerance: A secondary analysis of the EXPLORER-HCM randomized trial
  • Sodium-glucose cotransporter 2 inhibitors may reduce incidence of obstructive airway disease
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options