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Ibrutinib plus Venetoclax show promising results for first-line treatment of chronic lymphocytic leukemia

...s 93% (95% CI, 88%-99%) with an overall survival rate of 96% (95% CI, 92%-100%). While patients had variable outcomes, remission rates and PFS rates, the study found that no participants had CLL progression while taking the combined therapy. The study results focused on the impact of the combined therapy on CLL, however it is worth noting that participants had side effects, adverse events, complications, and one possible treatment-associated death...

Cardiovascular safety of hydroxychloroquine in veterans with rheumatoid arthritis

...ign. The primary outcomes were incident long QT syndrome (LQTS), arrhythmia-related hospitalization, and all-cause mortality. 4,426 veterans with RA treated with HCQ (mean [SD] age = 63.9 [12.0] years, 13.8% female) were matched with 4,426 veterans with RA treated with a disease-modifying antirheumatic drug (DMARD) other than HCQ (mean [SD] age = 63.9 [11.9] years, 14.2% female). There were found to be 3 LQTS events and 56 arrhythmia-related hospi...

Risk factors for SARS-CoV-2 seropositivity in health care workers

...w York City area In-Depth [cross-sectional study]: Of the approximately 30,000 employees and staff in the Emory healthcare system, 10,275 (35%) participated in voluntary serological testing from 19 April through 26 June 2020 at seven centers throughout the Atlanta, GA metropolitan area. The enzyme-linked immunosorbent assay had an estimated sensitivity of 97.5% and specificity of 98.0%. Demographic information and data regarding the use of persona...

Smoking and cardiovascular disease may explain sex-related differences in mortality

...r men has consistently been found to be lower than women, although the male-to-female mortality ratio has decreased over the last 30 years. It has been thought that this gap in mortality is due to biological differences, which confer greater resilience in women. However, gender as a social construct may tie into societal, cultural, and economic factors that influence mortality, such as one’s occupation, or one’s health lifestyle factors. Since the...

Social vulnerability influences coronavirus disease 2019 outcomes in major cities

...reas of higher social vulnerability (global Moran I, 0.198 to 0.803, P < 0.001 in all cases except confirmed cases in Philadelphia, with P = 0.011). Areas such as the South and West sides of Chicago, the Bronx and Queens in New York City, and North and Northeast Philadelphia had high positivity rates. Furthermore, one standard deviation higher value of the SVI index in Chicago, New York, and Philadelphia was associated with higher positivity (40%,...

Epidemiological and virological characteristics of respiratory tract infections in children during COVID-19 outbreak

...o the same period in 2018 and 2019. Specifically, it reduced by 57.4% (288,003 vs. 676,704) from 2019 and by 59.9% (288,003 vs. 717,983) from 2018. The total number of pediatric respiratory infections from January to April, 2020 was lower than the number in 2018 and 2019. It decreased by 59.0% (119,532 vs. 291,557) when compared to 2019 and by 65.7% (119,532 vs. 348,762) from 2018. The number respiratory tests completed declined significantly from...

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