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Mixed vaccination with ChAdOx1-S followed by BNT162b2 induces a robust humoral immune response

...53-8161.96 at day 14 vs. 71.46 BAU/mL, 95% CI 59.84-85.33 at baseline, p<0.0001). The intervention-to-control ratio was 36.41 (95% CI 29.31-45.23) for trimeric spike protein and 77.69 (95% CI 59.57-101.32) for RBD protein. The secondary outcome of neutralizing antibodies was measured in both the intervention (BNT162b2) and control group. Geometric mean titers of neutralizing antibodies were significantly higher in the intervention group (1905.69 ,...

Analysis of the short and long-term in-hospital complications following diagnosis of COVID-19

...se 2019 in China In-depth [prospective cohort]: Between Jan 17 and Aug 4, 2020, 80 388 patients were enrolled from 302 clinical sites in the UK. Included patients were adults ≥19 years old with suspected or laboratory confirmed COVID-19. Those with duplicate patient records and no in-hospital complication were excluded. Overall, 36 367 patients (49.7%) had ≥1 in-hospital complication and were included in the final analysis. Among enrolled patients...

Wellness Check: Mental Health

...ceding their ED visit. Patients who were male, from a rural community (<10,000 residents), immigrants, not followed by a primary care physician, and who presented with substance use disorder were more likely to present without 2-year history of outpatient care. One limitation of this study was that there were no controls for external mental health programs that patients could have accessed previously, such as privately funded programs or utilizati...

Association between BMI and diabetes risk among low-middle income countries varies considerably by geographical...

...completed, a search was done for a suitable comparable survey done after 2008 with a 50% or higher response rate. In total, there were 58 surveys analyzed (9 non-STEPS) from 57 LMICs. Diabetes was defined as fasting plasma glucose > 7.0 mmol/L, random plasma glucose > 11.1 mmol/L, or a HbA1C > 6.5%. If no values were available, then the use of a diabetes medication was sufficient. The most used measurement to confirm diabetes was POC fasting gluc...

COVID-19 lockdowns associated with increased quiet time and less spoken communication for children with...

...e was a slight increase during the peri-COVID-19 period in daily hours of 40-49 dBA input (0.26 h, 95% CI 0.03-0.55 h). As well, there was a decrease in input at 60-69 dBA (-0.49 h, 95% CI -0.21 to -0.8 h) and 70-79 dBA (-1.70 h, 95% CI -1.42 to -1.99 h). Furthermore, there was more time spent in quiet (0.76 h, 95% CI 0.27-1.26 h), and less time spent in speech alone versus speech with competing background noise (-1.38 h, 95% CI -0.88 to -1.87 h)....

Upadacitinib monotherapy is effective for patients with moderate-to-severe atopic dermatitis

...essed in the Measure Up 2 (MU2) study (between July 27, 2019, and Jan 17, 2020). Included patients were adolescents (aged 12-17 years) and adults (aged 18-75 years) with moderate-to-severe atopic dermatitis (defined by ≥ 10% of body surface area affected by atopic dermatitis, EASI ≥ 16, vIGA-AD ≥ 3, and WP-NRS ≥ 4). Patients were randomly assigned to receive oral upadacitinib 15 mg, 30 mg, or placebo once daily for 16 weeks. Altogether, 847 patien...

Home health management of patients undergoing deep brain stimulation for Parkinson’s disease is safe...

...t was 0.4 (0.80) visits for those in the home health management group (P<0.001). From the 23 participants in the home health visit group, 3 had single clinic visits and 2 participants had 2 clinic visits. The study found no difference in the total number of postoperative management visits (sum of in-person and telemedicine visits for SOC group (4.8 [0.4]) compared to home health group (5.2 [0.7]); P= 0.06). There were no significant differences fo...

Bidirectional relationship between subjective age and frailty

...ng categories were then used to define the number of criteria met: robust (0), pre-frailty (1-2), frailty (≥3). Subjective age was determined by self-report and was a response to the age that the participants feel most of the time. These categories comprised 45%, 46%, and 9% of participants, respectively. Approximately 77% of participants felt younger than their chronological age while 18% felt the same age and 5% felt older. Feeling older than on...

Annual screening for ovarian cancer does not significantly reduce mortality

...creasing cancer detection. However, this randomized control trial of over 200 000 women in the UK did not find a significant reduction in mortality with annual MMS or USS screening compared to no screening. Interestingly, MMS increased detection of stage I disease compared to no screening, but this was not adequate to reduce mortality rates. While these results may indicate no benefit of annual screening in the general population, they have limite...

Hypothermic machine perfusion reduces nonanastomic biliary strictures risk in liver transplantation

...andard of care (hazard ratio [HR], 0.36; 95% confidence interval [CI], 0.14-0.94; P = 0.03). Furthermore, postperfusion syndrome (relative risk ratio [RR], 0.43; 95% CI, 0.20-0.91) and early allograft dysfunction (RR, 0.61; 95% CI, 0.39-0.96) were less in the machine-perfusion group compared to the standard of care. The number of treatments for the machine perfusion group was less by almost a factor of four compared to the control group. Reported...

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