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2 Minute Medicine Rewind October 20 – October 27, 2014

...o the practices owned by local hospital or multi-hospital organizations. Genetic and Environmental Risk Assessment and Colorectal Cancer Screening in an Average-Risk Population Adherence to chronic screening programs, including the colorectal cancer screening, remains a significant problem. The use of individualized genetic and environmental risk assessments (GERA) for colorectal cancer susceptibility has been thought to possibly improve adherence...

Support sheets for patients did not reduce low value screening tests

...ncurred by these services, many screening tests have been found to deliver net harm on a population-based level. Patient education is one potential site of intervention to decrease the prevalence of inappropriate testing. This study aimed to identify if a brief, evidence-based decision support sheet would alter patient intention to receive low-value testing. The study investigators used four types of single-page evidence-based decision support she...

2 Minute Medicine Rewind September 17, 2018

...oral access (14.2% vs. 15.7%, OR 0.89, 95% CI 0.80 to 1.00, p=0.0526). The net number of adverse clinical events, however, was fewer in the radial access group when compared to femoral access group (15.2% vs. 17.2%, OR 0.87, 95% Cl 0.78 0.97, p=0. 0128). There were no differences in major adverse cardiovascular or net adverse clinical events between heparin and bivalirudin groups. This study therefore shows that in patients with acute coronary syn...

Anti-HLA antibodies predict worse kidney-allograft survival

...plement-binding antibodies improved discrimination capacity and continuous net reclassification in the reference model. These results highlight the need for therapies targeting complement to improve survival in patients with complement-binding anti-HLA antibodies. The study has a strong design with over 1000 subjects and is well-controlled for subgroup differences, especially populations across the two transplant centers in Paris. Click to read th...

Text messaging program for diabetes shows improved medication adherence

...sed intervention could improve the health of diabetic patients in a safety net ED. Though it found trends towards improvement in HbA1c levels and all secondary outcomes, none reached statistical significance. With these findings, the authors declare the program a success and the study yet another data point in the growing evidence-base for text-based interventions as a scalable and cost-effective adjunct tool for chronic disease management. Furthe...

Women’s Health Initiative results in high-value economic return

...er incidence, and decreased cardiovascular disease incidence. Overall, the net monetary benefit of the WHI trial was $49.5 billion, which exceeded the cost of the $260 million trial itself. The major weaknesses of this study are the simplification of the model, which could not account for all potential cHT associations, and the lack of consideration for nonmedical and indirect costs. However, this model demonstrated that in addition to the clinica...

Physicians report feeling moral distress over hospital policies that force inadequate care based on...

...has several limitations. First, the study was conducted in only two safety net systems, and it may not be applicable to other training environments. Furthermore, there may have been an inherent response bias from participants, where negative experiences and perceptions were minimized due to social desirability. Strengths of this study include that it looked to evaluate clinicians’ experiences with this policy, rather than only the patients’ experi...

Fibrosis linked with mortality in nonischemic dilated cardiomyopathy patients

...correct risk reclassifications using the proposed schema by the authors. Nonetheless, this study provides a solid foundation for the potential clinical use of midwall fibrosis as a mortality predictor in dilated cardiomyopathy patients. Click to read the study, published today in JAMA By John Prendergass and Rif Rahman More from this author: Protected sleep periods improve intern alertness and sleep duration , ADHD medication decreases rates of cr...

Chest radiograph neural network predicts lung cancer in smokers

...y to non-smokers. In summary, this study demonstrated that a deep-learning network based on electronic health data is comparable to current high performing models without smoking history as an input. Click here to read the study, published today in Annals of Internal Medicine Relevant Reading: Selection Criteria for Lung-Cancer Screening In-Depth [retrospective cohort]: This study trained a neural network using the PLCO (Prostate, Lung, Colorectal...

USPSTF recommends routinely screening asymptomatic women for chlamydia and gonorrhea

...hat screening of pregnant women to avoid ophthalmia neonatorum provided no net benefit because universal ocular prophylaxis of newborns is very effective and the prevalence of infection is low in this group. Screening for both chlamydia and gonorrhea should be done simultaneously using the highly sensitive nucleic acid amplification tests (NAATs). Click to read the study, published today in AIM Relevant Reading: Recommendations for the laboratory-...

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