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USPSTF recommends routinely screening asymptomatic women for chlamydia and gonorrhea

...hat screening of pregnant women to avoid ophthalmia neonatorum provided no net benefit because universal ocular prophylaxis of newborns is very effective and the prevalence of infection is low in this group. Screening for both chlamydia and gonorrhea should be done simultaneously using the highly sensitive nucleic acid amplification tests (NAATs). Click to read the study, published today in AIM Relevant Reading: Recommendations for the laboratory-...

2 Minute Medicine Rewind December 16-22, 2013

...or verbal memory and fluency, a strong predictor of Alzheimer disease. The net difference between the multivitamin and placebo groups was -0.01 (p=0.53) for global composite score; -0.005 (p=0.80) for verbal memory score; 0.02 (p=0.79) for the Telephone Interview for Cognitive Status score; and -0.07 (p=0.59) for category fluency score. The study participants as a whole had a slower rate of decline than would be expected in the general population,...

#VisualAbstract: Personalized Prediction of Cardiovascular Benefits and Bleeding Harms From Aspirin for Primary Prevention

...hat when a CVD event was considered equivalent to 2 major bleeding events, net benefits of aspirin increased to 21% of women and 41% of men. Patients with more CVD risk factors (including hyperlipidemia, hypertension, diabetes, smokers) and those with lower bleeding risk factors benefited more from aspirin treatment. Despite the significance of these results, one limitation of this study was the generalizability of findings given that the study to...

Support sheets for patients did not reduce low value screening tests

...ncurred by these services, many screening tests have been found to deliver net harm on a population-based level. Patient education is one potential site of intervention to decrease the prevalence of inappropriate testing. This study aimed to identify if a brief, evidence-based decision support sheet would alter patient intention to receive low-value testing. The study investigators used four types of single-page evidence-based decision support she...

2 Minute Medicine Rewind September 17, 2018

...oral access (14.2% vs. 15.7%, OR 0.89, 95% CI 0.80 to 1.00, p=0.0526). The net number of adverse clinical events, however, was fewer in the radial access group when compared to femoral access group (15.2% vs. 17.2%, OR 0.87, 95% Cl 0.78 0.97, p=0. 0128). There were no differences in major adverse cardiovascular or net adverse clinical events between heparin and bivalirudin groups. This study therefore shows that in patients with acute coronary syn...

Anti-HLA antibodies predict worse kidney-allograft survival

...plement-binding antibodies improved discrimination capacity and continuous net reclassification in the reference model. These results highlight the need for therapies targeting complement to improve survival in patients with complement-binding anti-HLA antibodies. The study has a strong design with over 1000 subjects and is well-controlled for subgroup differences, especially populations across the two transplant centers in Paris. Click to read th...

Text messaging program for diabetes shows improved medication adherence

...sed intervention could improve the health of diabetic patients in a safety net ED. Though it found trends towards improvement in HbA1c levels and all secondary outcomes, none reached statistical significance. With these findings, the authors declare the program a success and the study yet another data point in the growing evidence-base for text-based interventions as a scalable and cost-effective adjunct tool for chronic disease management. Furthe...

Women’s Health Initiative results in high-value economic return

...er incidence, and decreased cardiovascular disease incidence. Overall, the net monetary benefit of the WHI trial was $49.5 billion, which exceeded the cost of the $260 million trial itself. The major weaknesses of this study are the simplification of the model, which could not account for all potential cHT associations, and the lack of consideration for nonmedical and indirect costs. However, this model demonstrated that in addition to the clinica...

Physicians report feeling moral distress over hospital policies that force inadequate care based on...

...has several limitations. First, the study was conducted in only two safety net systems, and it may not be applicable to other training environments. Furthermore, there may have been an inherent response bias from participants, where negative experiences and perceptions were minimized due to social desirability. Strengths of this study include that it looked to evaluate clinicians’ experiences with this policy, rather than only the patients’ experi...

Thrombolysis for pulmonary embolism may benefit younger patients, harm older patients

...different end-points. While this study suggested that thrombolysis have a net benefit for younger patients and net harm for older patients, further research is required before incorporating these results at the bedside. Click to read the study, published today in JAMA Relevant Reading: Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis In-Depth [systematic review and meta-analysis]: This study includ...

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