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2 Minute Medicine Rewind December 16-22, 2013

...tween the short-term and long-term groups (6.0% and 5.8% respectively, p=0.002 for noninferiority). Additionally, between 90 days and 1 year, there was no significant association between therapy duration and occurrence of death or cerebrovascular events (HR 1.19, 95%CI 0.74-1.90). Notably, stent thrombosis after 90 days occurred in 0.3% of the short-term therapy group vs 0.1% of the long-term group, though this was not statistically significant (H...

Support sheets for patients did not reduce low value screening tests

...r intention to accept screening after intervention (-0.12, 95% CI -0.22 – -0.02). There was improvement in a few secondary outcomes (disease specific knowledge, perceived disease severity, disease-specific screening attitudes, and self-efficacy for screening). Image: PD ©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No articl...

#VisualAbstract: Personalized Prediction of Cardiovascular Benefits and Bleeding Harms From Aspirin for Primary Prevention

...nd bleeding risk scores, the true proportion of patients who experienced a net benefit may be higher than reported. Future studies should further compare the threshold of CVD risk above which aspirin is beneficial to the threshold of bleeding risk above which aspirin is harmful. To help make these decisions at present, it is important for both the clinician and patient to discuss the risks and benefits of aspirin to decide what is best for them. C...

IV alteplase improves functional outcomes in patients with stroke of unknown onset

...eserved for patients with known time of symptom onset, but in approximately 20-25% of patients with stroke, time of symptom onset is unknown. However, several individual trials utilizing imaging biomarkers to select patients with unknown time of stroke onset for IV thrombolysis have shown promise with net clinical benefit. This systematic review and meta-analysis included individual patient data from four randomized-controlled trials comparing IV...

Text messaging program for diabetes shows improved medication adherence

...the US; Silent myocardial infarctions more common than previously assumed © 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHC...

2 Minute Medicine Rewind December 31, 2018

...to prevent a single readmission, with accompanying costs ranging from $41,000 to $1.4 million (for dorsal and lumbar spinal fusion). This study therefore shows a lack of robust association between index hospitalization LOS and hospital readmission among children, with few diagnoses demonstrating an inverse association between LOS and readmission. Effect of intranasal ketamine vs. fentanyl on pain reduction for extremity injuries in children: the...

#VisualAbstract: Neoadjuvant degarelix versus triptorelin in premenopausal patients who receive letrozole for locally advanced...

...the control group (median 3 vs. 14 days, HR 3.05, 95% CI 1.65 to 5.65, p<0.001). OFS was also maintained during subsequent cycles for all patients that received degarelix and letrozole. Conversely, 15.4% of patients in the control group had suboptimal OFS after the first cycle. This study therefore shows that in premenopausal women receiving letrozole for NET, OFS is achieved more quickly and sustained more effectively with the use of degarelix as...

2 Minute Medicine Rewind October 20 – October 27, 2014

...ol hospitals (difference in differences of 1.8, 95% CI: 0.5% to 3.1% p = 0.007). Both converting hospitals and control hospitals improved their process quality metrics, but the difference in differences between the two groups was not statistically significant. The changes in mortality rates for Medicare patients between the two groups were also not statistically significant. Similarly, over this time period, the changes in the annual Medicare volu...

Global surveillance of cancer trends reveals wide variances in survival rate [CONCORD-2 study]

...rvival were analyzed for survival trends for the 15-year period from 1995-2009, covering 25.7 million adults (age 15-99) and 75,000 children (age 0-14 years). The study evaluated trends for cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, as well as trends for adult and childhood leukemia. Global cancer survival trends varied widely in both 5-year survival trends over time and between natio...

Intervention to reduce low-value preoperative care for patients undergoing cataract surgery

...intervention patients and 585 control patients during the first year and 1002 intervention patients and 511 control patients in the 12 month sustainability analysis. In the first year of analysis, preoperative visits decreased from 93% to 24% in the intervention group and increased from 89% to 91% in the control group. Chest x-rays decreased from 90% to 24% versus an increase from 75% to 83%, lab testing decreased from 92% to 37% versus a decreas...

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