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Global surveillance of cancer trends reveals wide variances in survival rate [CONCORD-2 study]

...based study (CONCORD) In-Depth [retrospective cohort]: This study analyzed net 5-year survival trends in order to gauge effectiveness of health care systems and inform global cancer control policy. Data from 279 population-based databases with publishable reports or known follow-up on survival were analyzed for survival trends for the 15-year period from 1995-2009, covering 25.7 million adults (age 15-99) and 75,000 children (age 0-14 years). The...

2 Minute Medicine Rewind October 20 – October 27, 2014

...o the practices owned by local hospital or multi-hospital organizations. Genetic and Environmental Risk Assessment and Colorectal Cancer Screening in an Average-Risk Population Adherence to chronic screening programs, including the colorectal cancer screening, remains a significant problem. The use of individualized genetic and environmental risk assessments (GERA) for colorectal cancer susceptibility has been thought to possibly improve adherence...

Experimental malaria vaccine confers modest, short-term protection

...ncer drug beats current first-line treatment in phase 3 trial, A molecular link between sleep deprivation and insulin resistance, A phase I trial of neural stem cells in a disease of myelination shows promising results, Diagnostic exome sequencing in persons with severe intellectual disability finds new candidate genes, HPV vaccine associated with minimal adverse effects, Four different types of breast cancer revealed based on molecular data, Acup...

Repeat bone mineral density testing may not improve prediction of fracture outcomes

...ogy and duration associated with cardiac resynchronization outcomes, New genetic link between type 2 diabetes and coronary heart disease © 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors,...

Maternal anti-epileptic use linked to autism disorders in offspring

...Therefore, the accuracy of the results cannot be definitely determined. Nonetheless, the authors present a very robust increase in absolute ASD risk associated with valproate use, and any variations due to false positive diagnoses are likely irrelevant. While the cross-sectional study design has inherent limitations and biases, it still lends strong support to the proposed link between AEDs and ASDs in the absence of prospective studies. Further...

Longer-duration breast feeding not associated with lower risk of obesity in childhood

...diameter useful in determining frequency of surveillance , Maternal folic acid supplementation during early pregnancy associated with lower risk of autism , Energy drinks may be harmful to the health of adolescents , Early initiation of antiretroviral therapy linked with lower risk of cognitive impairment in HIV © 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer...

New mutations behind heritable hypercalcemia and hypocalcemia identified

...he role of Gɑ 11 in forms of hypercalcemia and hypocalcemia by combining genetic, in vitro and protein modeling data. However, Gɑ 11 mutations are not the final word on FHH or autosomal dominant hypocalcemia. Only 3 of the 18 unrelated patients tested had Gɑ 11 mutations. The mutations in the other 15 remain unknown. By Tomi Jun and Mitalee Patil More from this author: Researchers improve lung cancer risk model by incorporating more risk factors,...

Meta-analysis supports Institute of Medicine’s vaccine safety findings

...measles/mumps/rubella (MMR) vaccine is not linked to autism but that it is linked to a risk of febrile seizures. 2. There is moderate evidence that links the rotavirus vaccination to a risk of intussusception and the hepatitis A vaccine to purpura. 3. There is strong evidence that vaccinations are not associated with childhood leukemias. Evidence Rating Level: 2 (Good) Study Rundown: Immunizations have significantly reduced the incidence of infect...

Increased diabetes risk observed in gout patients

...ment on the effect of dietary factors, such as sugar drink intake, a clear link between gout and increased diabetes risk was thoroughly established. A follow up prospective cohort study would help validate the findings of this case-control study. Click to read the study, published the Annals of Rheumatic Disease Relevant Reading: Gout and the risk of type II diabetes among men with a higher cardiovascular risk profile In-Depth [case-control study]...

Proton pump inhibitor use associated with development of chronic kidney disease

...most prescribed medications, often without a strong indication, have been linked to acute kidney injury (AKI). The theory is that recurrent bouts of AKI may lead to CKD. This study, which used data from two prospective cohorts, was conducted to evaluate the link between PPIs and incident CKD. The results of the study showed that use of proton pump inhibitors (PPIs) was associated with about 20 – 50% higher risk of developing chronic kidney diseas...

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