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Quick Take: Neoadjuvant degarelix versus triptorelin in premenopausal patients who receive letrozole for locally...

...s with breast cancer receiving letrozole as neoadjuvant endocrine therapy (NET). In this randomized controlled trial, 51 premenopausal women with stage cT2 to 4b, estrogen receptor and progesterone receptor greater than 50%, and human epidermal growth factor receptor 2-negative invasive breast cancer were randomized to receive triptorelin 3.75 mg (administered intramuscularly on day 1 of every cycle) or degarelix 240 mg (administered subcutaneousl...

Thrombolysis for pulmonary embolism may benefit younger patients, harm older patients

...dy suggested that thrombolysis have a net benefit for younger patients and net harm for older patients, further research is required before incorporating these results at the bedside. Click to read the study, published today in JAMA Relevant Reading: Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis In-Depth [systematic review and meta-analysis]: This study included 16 RCTs through April 2014 that co...

IV alteplase improves functional outcomes in patients with stroke of unknown onset

...h unknown time of stroke onset for IV thrombolysis have shown promise with net clinical benefit. This systematic review and meta-analysis included individual patient data from four randomized-controlled trials comparing IV alteplase with placebo or standard of care in adults with stroke of unknown time of onset. Patients were selected using imaging biomarkers (MRI diffusion weighted imaging-fluid attenuated inversion recovery [DWI-FLAIR] mismatch...

#VisualAbstract: Neoadjuvant degarelix versus triptorelin in premenopausal patients who receive letrozole for locally advanced...

...s with breast cancer receiving letrozole as neoadjuvant endocrine therapy (NET). In this randomized controlled trial, 51 premenopausal women with stage cT2 to 4b, estrogen receptor and progesterone receptor greater than 50%, and human epidermal growth factor receptor 2-negative invasive breast cancer were randomized to receive triptorelin 3.75 mg (administered intramuscularly on day 1 of every cycle) or degarelix 240 mg (administered subcutaneousl...

Fibrosis linked with mortality in nonischemic dilated cardiomyopathy patients

...ed cardiomyopathy at the Royal Brompton Hospital in London between November 2000 and December 2008. Follow-up was accomplished via telephone calls or postal questionnaire at 6-month intervals. Overall, mortality occurred in 26.8% of midwall fibrosis patients and 10.6 % of those without midwall fibrosis. Patients with midwall fibrosis were also 5 times more likely than those without it to experience sudden cardiac death, appropriate ICD shock, nonf...

#VisualAbstract: Personalized Prediction of Cardiovascular Benefits and Bleeding Harms From Aspirin for Primary Prevention

...hat when a CVD event was considered equivalent to 2 major bleeding events, net benefits of aspirin increased to 21% of women and 41% of men. Patients with more CVD risk factors (including hyperlipidemia, hypertension, diabetes, smokers) and those with lower bleeding risk factors benefited more from aspirin treatment. Despite the significance of these results, one limitation of this study was the generalizability of findings given that the study to...

Women’s Health Initiative results in high-value economic return

...er incidence, and decreased cardiovascular disease incidence. Overall, the net monetary benefit of the WHI trial was $49.5 billion, which exceeded the cost of the $260 million trial itself. The major weaknesses of this study are the simplification of the model, which could not account for all potential cHT associations, and the lack of consideration for nonmedical and indirect costs. However, this model demonstrated that in addition to the clinica...

Text messaging program for diabetes shows improved medication adherence

...mes, increases healthy behaviors, and decreases ED utilization in a safety net population. 128 adult patients with poorly controlled diabetes (glycosylated hemoglobin [Hb A1C] level ≥8%) in an urban, public ED were enrolled in the study and randomly assigned to receive either two daily text messages for six months in English or Spanish or no text messages. The primary outcome of interest was the change in Hb A1C at 6 months between groups. Seconda...

Anti-HLA antibodies predict worse kidney-allograft survival

...the reference model improved risk stratification, as shown by a continuous net reclassification improvement of 0.75 (95% CI, 0.54 to 0.97). By Xiaozhou Liu and Adrienne Cheung More from this author: Nivolumab plus ipilimumab shows promise for metastatic melanoma, Prophylactic platelet transfusions prevent bleeding in hematologic cancers, Azithromycin is not associated with increased cardiovascular death in low-risk groups, Health education module...

2 Minute Medicine Rewind September 17, 2018

..., p=0. 0128). There were no differences in major adverse cardiovascular or net adverse clinical events between heparin and bivalirudin groups. This study therefore shows that in patients with acute coronary syndrome, radial access was associated with lower rates of adverse clinical events compared with femoral access, but not major adverse cardiovascular events at 1 year. Prevalence of cannabis use in electronic cigarettes among US youth The use o...

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