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#VisualAbstract: Drug-coated balloons are noninferior to drug-eluting stents for treatment of small vessel coronary...

...study findings at the 3-year follow-up lacked statistical significance. Nonetheless, this is the largest randomized controlled trial assessing the safety and efficacy of drug-coated balloons versus drug-eluting stents in patients with small vessel coronary artery disease. Click to read the study in The Lancet Relevant Reading: Drug-Coated Balloon Angioplasty Versus Drug-Eluting Stent Implantation in Patients With Coronary Stent Restenosis In-dept...

Genetic mutations may protect infants born to drug-using mothers

...on decreases rates of criminality in ADHD patients, Low dose aspirin shows net clinical benefit in patients with first unprovoked venous thromboembolism © 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the au...

Soaring rates of peripheral artery disease, now over 200 million cases worldwide

...he prevalence of PAD from 164 million in 2000 to 202 million in 2010 for a net increase of 23.5%. This rise was seen in both high and low-middle income countries with no significant difference in age-specific prevalence. However, in high-income countries, those diagnosed with PAD were equally likely to be men and while those diagnosed in low-middle income countries were more likely to be women. Finally, of 15 risk factors analyzed, there were seve...

Quick Take: Effect of lorcaserin on prevention and remission of type 2 diabetes in...

...normoglycemia. At 1 year, diabetic patients treated with lorcaserin had a net weight loss of 2.6 kg when compared to placebo (95% CI 2.3 kg to 2.9 kg, p<0.0001). Prediabetic patients and those with normoglycemia also experienced significant weight loss compared to placebo (p<0.0001). Lorcaserin resulted in a non-significant increase in the rate of achievement of normoglycemia in patients with prediabetes (9.2% vs. 7.6%, HR 1.20, 95% Cl 0.97 to 1....

Rare TREM-2 mutation implicated in Alzheimer’s Disease

...in risk of AD. The authors of this study aimed to assess low-prevalence genetic variants which may greatly increase the risk of late-onset AD. Background reading: 1. Alzheimer’s disease (Review) 2. The genetics of Alzheimer’s Disease 3. TREM2 variants in Alzheimer’s Disease This [retrospective cohort]: This study utilized whole genome sequencing on 2,261 Icelanders resulting in 191,777 genetic variants found in the population. In analyzing 3,550...

Periodontitis therapy not improving HbA1C levels in type II diabetes patients

...on decreases rates of criminality in ADHD patients, Low dose aspirin shows net clinical benefit in patients with first unprovoked venous thromboembolism, Rare TREM-2 mutation implicated in Alzheimer’s Disease ©2012-2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post shoul...

3D mammography (tomosynthesis) enhances accuracy of breast cancer screening

...ion decreases rates of criminality in ADHD patients,Low dose aspirin shows net clinical benefit in patients with first unprovoked venous thromboembolism, Rare TREM-2 mutation implicated in Alzheimer’s Disease Image: PD ©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No...

Evolocumab significantly reduces LDL cholesterol in familial hypercholesterolemia patients [TESLA-B and RUTHERFORD-2 studies]

...Both trials were well-designed double-blind trials. One limitation is that net clinical outcomes, such as reductions in cardiovascular death, were not among the primary endpoints. As a result, large-scale studies of much longer follow-up periods are needed to determine the clinical benefits of evolocumab. Both studies are funded by Amgen Inc. Click to read the TESLA-B study, published today in The Lancet Click to read the RUTHERFORD-2 study, publi...

Lomitapide reduces LDL-C by 38% in patients with devastating homozygous familial hypercholesterolemia

...hylomicrons and very-low-density lipoprotein (VLDL) particles resulting in net LDL-particle reduction. Lomitapide does not depend on functional LDL-receptors, unlike statins, where inhibition of HMG-CoA reductase results in the upregulation of hepatic LDL-receptors and increased clearance of circulating plasma LDL-particles. Thus, lomitapide is a promising treatment strategy for HoFH. Background reading: 1. An MTP Inhibitor That Normalizes Atherog...

Lorazepam not superior to diazepam for pediatric status epilepticus

...ion decreases rates of criminality in ADHD patients,Low dose aspirin shows net clinical benefit in patients with first unprovoked venous thromboembolism, Rare TREM-2 mutation implicated in Alzheimer’s Disease ©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post shoul...

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