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2 Minute Medicine Rewind April 26, 2021

...e associated with an increased risk of gastrointestinal (GI) bleeds, sepsis, and pneumonia during the first month of therapy initiation. Evidence level rating: 2 (Good) Oral corticosteroids are commonly prescribed to children for various inflammatory conditions, including asthma, inflammatory bowel disease, and bronchitis. Though the adverse effects of long-term corticosteroid use have been thoroughly explored in scientific literature, the short-t...

2 Minute Medicine Rewind February 8, 2021

...ed greater radiographic severity, female sex, greater knee pain, higher BMI, and older age. Evidence Rating Level: 2 (Good) Knee osteoarthritis (OA) has a peak prevalence at age 50 worldwide, which dramatically impacts middle-aged individuals in terms of quality of life and ability to work. Currently, the use of total knee replacement (TKR) is on the rise for middle-aged patients, although TKR done too early has been linked to lower patient satisf...

2 Minute Medicine Rewind March 16, 2020

...on rate (GFR), an integral component of establishing drug dosing, prognosis, and treatment of patients with kidney disease, is often measure indirectly through serum creatinine levels to develop an estimate (eGFR). This estimation is adjusted by height, weight, age, sex, and race due to the susceptibility of serum creatinine to muscle mass, diet, and GFR. This investigation of a pooled data set from 10 studies of individuals with and without chron...

2 Minute Medicine Rewind June 15, 2020

...rugs of choice. DOACs are known to be substrates of CYP3A4 enzyme complexes, and are thus susceptible to potentially dangerous drug-drug interactions. This retrospective cohort study involved 24,943 older adults (M [SD] age = 77.6 [7.2] years, 51.0% women) living in Ontario, Canada, taking DOACs, and assessed whether co-prescription of either clarithromycin or azithromycin, macrolide antibiotics commonly prescribed for respiratory infections and k...

2 Minute Medicine Rewind March 23, 2020

...d death was associated with older age, d-dimer levels greater than 1.0μg/mL, and higher Sequential Organ Failure Assessment upon assessment. 2. Median viral shedding in survivors was 20 days but was present until death in fatal cases. 3. Hypertension, diabetes, and coronary artery disease were the most common comorbidities in the sample of patients with laboratory-confirmed SARS-CoV-2 infection. Evidence Rating Level: 2 (Good) Coronavirus disease...

2 Minute Medicine Rewind September 21, 2020

...dy age score, reduce smoking habits, lower risk factors for chronic disease, and lower rates for metabolic syndrome. Evidence Rating Level: 2 (Good) As life expectancy in western countries continues to rise, the legislated retirement age is also expected to increase. However, inactive lifestyles contributing to obesity and other health conditions are barriers to a robust and healthy aging workforce. The workplace is a potential setting for a publi...

2 Minute Medicine Rewind May 31, 2021

...d cholecystitis during the pandemic have presented with more severe illness, and in Italy, there was higher rate of ectopic pregnancy rupture early in the lockdown. The current repeat cross-sectional study based in Ontario, Canada compared the rates of emergency department visits prior to and during the pandemic, for 4 common medical emergencies: Appendicitis, cholecystitis, ectopic pregnancy, and miscarriage. The clinical outcomes and management...

2 Minute Medicine Rewind April 6, 2020

...ng to Third International Consensus Definitions for Sepsis and Septic Shock, and had developed either sinus tachycardia, atrial fibrillation, or atrial flutter without a change in catecholamine dose. Seventy-five patients were randomized to the standard therapy group (including respiratory and fluid resuscitation, antimicrobials, and catecholamines), and 76 to the treatment group, consisting of standard therapy and landiolol hydrochloride infusion...

2 Minute Medicine Rewind August 9, 2021

...aced with choices regarding their care planning, palliative care directives, and life extending interventions. However, little is known about how spiritual and religious beliefs play into these decisions. This cross-sectional survey study aimed further explore this topic and better understand the association between dialysis patients’ religious and spiritual beliefs and their care preferences. The United States Renal Data System Study of Treatment...

2 Minute Medicine Rewind May 3, 2021

...ere not as likely to grow in culture, had higher cycle thresholds in RT-PCR, and had lower viral concentrations, compared to adult specimens. Evidence Rating Level: 2 (Good) Although the pediatric population is a substantial driver of common viral transmissions, such as the flu, there is conflicting evidence surrounding the extent of their role in COVID-19 transmissions. For instance, some studies have shown higher viral loads in children, whereas...

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