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2 Minute Medicine Rewind May 31, 2021

...as COVID-19 period. In total, 36,691 emergency room visits were included, 40.2% of which were for appendicitis. The results showed that there was a decrease in all visits at the start of the pandemic, but 5 weeks in, the visits for cholecystitis were returning to normal. The incident rate ratio (IRR) ranged from 0.60-0.76 for the first 3 weeks. For ectopic pregnancy, visits were below the historical volume for 3 weeks during the COVID-19 period, w...

2 Minute Medicine Rewind August 24, 2020

...n children of parents with high income and high educational attainment (HR 0.85, 95% Ci 0.81-0.89; HR 0.72, 95% CI 0.69-0.75 respectively). In terms of air pollution, exposure to particulate matter less than 2.5 um in a diameter was the only factor to be positively associated with asthma and persistent wheezing across all models. For every increase in pollutant concentration by 5 ug/m 3 , the HR was 1.05 (95% CI, 1.03-1.07). Study findings reinfor...

2 Minute Medicine Rewind May 3, 2021

...samples (95% CI 14-34%). Compared to the adult samples, the p-values were 0.003 and < 0.001 respectively for the 11-17 and under 10 age groups, and no significant difference was found between the pediatric age groups (p = 0.5). 48% of children under 10 had asymptomatic infections, compared to 24% of the 11-17 group and 7% of adults. Additionally, the cycle threshold for RT-PCR was lowest in adults (18.7, IQR 17.9-30.4) compared to 22.2 in the 11-...

2 Minute Medicine Rewind June 29, 2020

...experience chronic pain than those exercising less than once weekly (OR = 0.65, 95% CI = 0.53-0.78). For men, exercising nearly every day did not lower the risk for chronic pain as much as only 2-3 times per week (OR = 0.79, 95% CI = 0.65-0.98), whereas for women, exercising nearly every day lowered the risk for chronic pain the most (OR = 0.79, 95% CI = 0.70-0.88). The strength of these findings were only minimally impacted after adjusting for l...

2 Minute Medicine Rewind October 19, 2020

...serum 25-hydroxyvitamin D versus controls (53.1 nmol/L vs. 69.9 nmol/L, p=0.02). There was no statistically significant difference between parathyroid hormone levels between cases and controls (2.25 pmol/L and 2.38 pmol/L, respectively). Additionally, though 78% of women were taking at least 10 µg (400 IU) vitamin D daily, 43% had a vitamin D sufficiency (25-hydroxyvitamin D <50 nmol/L). Of note, there were significant differences in background c...

2 Minute Medicine Rewind October 5, 2020

...ribed to patients with nephrolithiasis for pain control; in fact, between 2007 and 2014, opioid use among individuals with a history of nephrolithiasis was significantly higher compared with those without. This retrospective cohort study examined 135 patients with symptomatic nephrolithiasis managed with either trial of passage (TOP) with medical expulsion therapy (MET) or with surgical intervention, consisting of either primary ureteroscopy (n =...

Upadacitinib plus topical corticosteroids is safe and effective for moderate-to-severe atopic dermatitis

...re randomly assigned 1:1:1 to two treatment groups (Upadacitinib 15 mg [n=300] or 30 mg [n=297] plus topical corticosteroids) or placebo group (placebo plus topical corticosteroids; n=304) for a 16-week treatment period. Treatment was given orally once daily, and patients were assessed for corticosteroid discontinuation as symptoms stabilized. At 16 weeks, a significantly greater proportion of patients in both upadacitinib groups achieved a EASI-7...

#VisualAbstract: Upadacitinib plus topical corticosteroids is safe and effective for moderate-to-severe atopic dermatitis;

...re randomly assigned 1:1:1 to two treatment groups (Upadacitinib 15 mg [n=300] or 30 mg [n=297] plus topical corticosteroids) or placebo group (placebo plus topical corticosteroids; n=304) for a 16-week treatment period. Treatment was given orally once daily, and patients were assessed for corticosteroid discontinuation as symptoms stabilized. At 16 weeks, a significantly greater proportion of patients in both upadacitinib groups achieved a EASI-7...

2 Minute Medicine Rewind August 9, 2021

...hort study assessed 2 465 387 pregnancies in Ontario, Canada between June 2002 and December 2020. Among this cohort, the mean birth rates were reported as 7.96% for preterm births and a stillbirth rate of 0.56%. This data was extrapolated from population health administrative databases over the past 17.5 years. Specifically, from the Canadian Institute for Health Information’s Discharge Abstract database (CIHI-DAD) as well as the Ontario Mother-Ba...

2 Minute Medicine Rewind August 17, 2020

...utcomes. Multivariable regression analyses were used and iodine intake of 100 ug per day was used as reference (aOR=1.0) as intakes of 100-150 ug/d were usually associated with the least adverse outcomes. Of non-supplement users, 75 ug iodine intake per day pregnancies were associated with higher risk of preeclampsia (aOR 1.14, 95% CI 1.08-1.22), preterm delivery <37 weeks (aOR 1.10, 95% CI 1.04-1.16), and reduced fetal growth z-scores (-0.08 SD,...

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