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2 Minute Medicine Rewind May 3, 2021

...samples (95% CI 14-34%). Compared to the adult samples, the p-values were 0.003 and < 0.001 respectively for the 11-17 and under 10 age groups, and no significant difference was found between the pediatric age groups (p = 0.5). 48% of children under 10 had asymptomatic infections, compared to 24% of the 11-17 group and 7% of adults. Additionally, the cycle threshold for RT-PCR was lowest in adults (18.7, IQR 17.9-30.4) compared to 22.2 in the 11-...

2 Minute Medicine Rewind April 26, 2021

...days after therapy), the IRR was 1.41 (95% CI, 1.27-1.57) for GI bleeds, 2.02 (95% CI, 1.55-2.64) for sepsis, 2.19 (95% CI, 2.13-2.25) for pneumonia, and 0.98 (95% CI, 0.85-1.13) for glaucoma. During the second post-treatment period (31-90 days after therapy), the IRR was 1.10 (95% CI, 1.02-1.19) for GI bleeds, 1.08 (95% CI, 0.88-1.32) for sepsis, 1.09 (95% CI, 1.07-1.11) for pneumonia, and 0.95 (95% CI, 0.85-1.06) for glaucoma. Overall, the stud...

2 Minute Medicine Rewind July 26, 2021

...ally over the next five cycles. The difference in least squares means was -0.15 in favour of the ASyMS group (95% CI -0.19 to -0.12, p < 0.001). Other sub-domains of the MSAS also demonstrated improvements in the ASyMS group, such as the global distress index (difference in LS means of -0.21, 95% CI -0.27 to -0.16, p < 0.001), psychological score (difference -0.16, 95% CI -0.23 to -0.10, p < 0.001), and physical score (difference -0.21, 95% CI -0....

2 Minute Medicine Rewind February 8, 2021

...amining pre-HTO characteristics associated with the conversion time. From 2002 to 2014, 643 knees in 556 patients had a medial opening wedge HTO procedure done, and by the end of the study in 2019, 103 TKRs (16.0%) were done. At 5 years, the cumulative incidence of conversion to TKR was 5%, and at 10 years, the incidence was 21%. Furthermore, for female patients the incidence was 7% and 32%, and for early-stage disease patients it was 2% and 13%,...

2 Minute Medicine Rewind April 19, 2021

...ise therapy using behavioral change theory. 103 patients (mean [SD] age = 60.3 [8.2] years, 58% female) were randomized to the intervention cohort – consisting of website access, guidance to increase physical activity, automated text messaging support, and home exercise programming – and 103 (mean [SD] age = 59.0 [8.5] years, 64% female) to the control cohort – consisting only of website access. The primary outcomes were pain using the 11-point Nu...

2 Minute Medicine Rewind September 13, 2021 

...riod. There were 66 participants in the control group (mean(SD) age= 17.1(4.0) years; 56.1% male) and 59 participants in the intervention group (mean(SD) age= 16.9 (3.3) years; 45.8% male). The primary outcome measured was days to recovery which was defined as a Post-Concussive Symptom Scale (PCSS) score of 3 points or less. The study found that female participants (HR, 0.34; 95% CI, 0.19-0.60) and participants in the screen time permitted group (...

2 Minute Medicine Rewind July 12, 2021

...ifferent with higher frequency of unprotected intercourse (risk difference 0.3%, 95% CI 0.3 to 0.8). Furthermore, timing did not have a significant impact either, with similar risks for participants who engaged in unprotected intercourse within the 5 days prior to insertion compared to days 6-14 prior (risk difference 0.2%, 95% CI 0.2 to 0.5). A limitation of this study was that participants were asked to self-report their unprotected intercourse...

2 Minute Medicine Rewind September 21, 2020

...ow-up was variable, with a median of 1.3 years and interquartile range of 1.0-2.1 years. At the follow-up, the health outcomes measured were changes in body age score, smoking habits, single risk factors, and metabolic syndrome. In total, 90 companies participated, with 3,843 employees undergoing both the BAI and the follow-up. The study found that body age decreased, with a drop of 0.6 years (95% CI -0.7 to -0.5) for men and 0.7 years (95% CI -0....

2 Minute Medicine Rewind February 22, 2021

...were recruited and, after propensity matching, the NOAC (mean [SD] age = 70.3 [11.7] years, 59.5% male) and warfarin (mean [SD] age = 70.4 [11.6] years, 59.0% male) cohorts each included 6,034 patients. Dementia was diagnosed in significantly fewer patients in the NOAC cohort than in the warfarin cohort (304 vs. 360, p = 0.0285). Furthermore, in a stratified analysis, the risk of dementia was lower among patients using NOACs when compared with wa...

2 Minute Medicine Rewind July 13, 2020

...(ICASAC) 5.3±3.2 lesions, and for the posterior circulation (ICASPC) 3.8±3.0 lesions. No significant association between ICASTC and memory was found (b = -0.02 per +1 lesion, 95% CI -0.05 to 0.00, where b is a linear regression coefficient representing the difference in Z-score per one lesion increase in ICAS burden), even after controlling for age, sex, education level, and reading ability. However, a significant association between ICASPC and m...

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