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2 Minute Medicine Rewind July 26, 2021

...minations. The current longitudinal study examined mTBI patients at 18 American Level 1 trauma centres at 2 weeks, 3, 6, and 12 months after injury. These results were then externally validated with another longitudinal cohort of 2594 mTBI patients from 55 European trauma centres. Patients with mTBI were those with Glasgow Coma Scale scores of 13 to 15 upon presentation to the emergency department. The primary outcome was the Glasgow Outcome Scale...

2 Minute Medicine Rewind April 19, 2021

...ticipants in the control cohort used massage, heat or cold, and topical anti-inflammatory drugs. Overall, this study provides robust evidence that a self-directed exercise regimen augmented by automated text messaging support significantly improves both pain and functional capacity for patients with knee OA. This easily scalable intervention may have a significant impact on population health and aid to reduce the burden of disease associated with...

2 Minute Medicine Rewind June 29, 2020

...examined. The results found that each healthy lifestyle practice was significantly associated with lower all-cause mortality in both the medication users and non-users groups (all P interaction > 0.25). When all 5 factors were pooled into a healthy lifestyle score, the hazards-ratio (HR) for all-cause mortality was 0.82 (95% CI, 0.81-0.82) for users and 0.81 (95% CI, 0.79-0.83) for non-users (P interaction = 0.54). For cancer, the HR was 0.82 (95%...

2 Minute Medicine Rewind June 14, 2021

...nada, postpartum people living in low income neighbourhoods had less significant visit increases compared to higher income neighbourhoods. Evidence Rating Level: 2 (Good) Postpartum mental illness affects approximately 1 in 5 mothers, and can present as anxiety, depression, bipolar disorder, psychotic disorders, alcohol and or substance abuse. This emotional burden on mothers also represents a clinical burden on the health care system with increas...

2 Minute Medicine Rewind April 26, 2021

...primary outcomes evaluated were antiplatelet use, any statin therapy, high-intensity statin (HIS) therapy, and statin adherence. Statin adherence was assessed using a validated measurement of proportion of days covered (PDC), calculated by dividing the prescription’s covered days supply by total days in the given period. There were 147,600 patients (10,413 women and 137,187 men) with premature ASCVD (<55 years) involved in the study. In this grou...

2 Minute Medicine Rewind October 12, 2020

...r hemorrhage, pre-hospital administration of tranexamic acid did not significantly improve 30-day mortality compared to a placebo. 2. 30-day mortality outcomes were higher in the treatment group, when tranexamic acid was administered within 1 hour of injury, when the patient underwent severe shock, or when 2 g of tranexamic acid were administered within 8 hours of hospital arrival. Evidence Rating Level: 1 (Excellent) In the treatment of trauma pa...

2 Minute Medicine Rewind July 12, 2021

...ected intercourse and emergency contraceptive insertion did not have significant effects on one-month post IUD pregnancy rates. Evidence Rating Level: 1 (Excellent) Prior studies have assessed the efficacy of emergency contraceptive methods, however the impacts of timing and frequency of episodes of unprotected intercourse have not been fully studied. More specifically, the current clinical guidelines from the World Health Organization (WHO) are f...

2 Minute Medicine Rewind February 22, 2021

...ale) cohorts each included 6,034 patients. Dementia was diagnosed in significantly fewer patients in the NOAC cohort than in the warfarin cohort (304 vs. 360, p = 0.0285). Furthermore, in a stratified analysis, the risk of dementia was lower among patients using NOACs when compared with warfarin if aged 65 to 74 years, if at a high risk of stroke as measured by the CHA2DS2-VASc score, and if at a high risk of bleeding as measured by the HAS-BLED s...

2 Minute Medicine Rewind May 3, 2021

...d < 0.001 respectively for the 11-17 and under 10 age groups, and no significant difference was found between the pediatric age groups (p = 0.5). 48% of children under 10 had asymptomatic infections, compared to 24% of the 11-17 group and 7% of adults. Additionally, the cycle threshold for RT-PCR was lowest in adults (18.7, IQR 17.9-30.4) compared to 22.2 in the 11-17 age group (IQR 18.3-29.0, p = 0.02) and 25.1 in the under 10 age group (IQR 17.7...

2 Minute Medicine Rewind February 8, 2021

...regnancy, were found to have similar pregnancy outcomes as the general American population. Evidence Rating Level: 2 (Good) Psoriasis is a chronic inflammatory skin disease affecting 7 million adults in the United States. It has been hypothesized that the chronic inflammatory state and association with psoriasis-related comorbid conditions such as diabetes and cardiovascular predispose pregnant women to complications. However, there is limited dat...

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