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Novel screening test may benefit variant Creutzfeldt-Jakob Disease patients

.... A new assay for detection of variant Creutzfeldt-Jakob Disease (vCJD) has 100% specificity, making it an ideal screening test for vCJD in prion-exposed populations. 2. The estimated sensitivity of the assay for vCJD-infected patient blood samples is around 70%. Evidence Rating Level: 1 (Excellent) Study Rundown: Prion diseases represent a class of fatal transmittable neurodegenerative diseases. A variant from of CJD (vCJD) is acquired through ex...

Patient Basics: Abortion (Termination of Pregnancy)

...stone is taken orally as a pill. Approved for use in the United States in 2000, this drug counters the effect of progesterone, a hormone necessary for pregnancy. More than 3 million women in Europe and China have received this drug to end a pregnancy. Side effects include nausea, vomiting, vaginal bleeding and pelvic pain. These symptoms usually can be treated with medications. In rare instances, there may be heavy bleeding. In that case, you may...

Patient Basics: Head Injury In Adults

...illion emergency department visits in the United States, with more than 72,000 deaths. An additional 80,000 to 210,000 people with moderate or severe head injuries become disabled or require extended hospital care. Overall, traumatic head injuries are the most common cause of death among Americans aged 45 and younger. In addition, head injuries resulting from falls are a very common cause of hospitalization and death among people older than 75. Me...

MIV-711 effective in reducing bone and cartilage manifestations for patients with osteoarthritis

1. In this double-blind phase 2a trial, cathepsin K inhibitor MIV-711 did not show a significant benefit in reducing pain but proved effective in delaying structural changes associated with progression of osteoarthritis. 2. Biomarkers of bone resorption were significantly reduced in both treatment groups but returned to baseline levels after treatment stopped at the end of the study. Evidence level: 1 (Excellent) Study Rundown: Cathepsin K is a c...

Sotagliflozin reduces cardiovascular risk for patients with diabetes and worsening heart failure

...y. The participants were randomized in a 1:1 ratio to receive once daily, 200 mg of sotagliflozin or placebo, respectively. The primary endpoint was the total number of deaths from cardiovascular causes, hospitalization for heart failure, and urgent visits for heart failure. During the study, a total of 600 primary endpoints occurred among the participants (245 in the sotagliflozin group and 355 in the placebo group). The rate of total primary end...

Patient Basics: Black Eye

...ed Duration Most of the swelling and discoloration go away within seven to 10 days after injury. The color of the skin around the eye will change over the course of recovery, typically showing green and yellow tones as the blood ages and is cleared from the tissue. Prevention Almost all eye injuries can be prevented. To decrease your risk of eye injuries: Use appropriate protective eyewear at work. Studies have shown that face shields, goggles and...

Patient Basics: Trigeminal Neuralgia (Tic Douloureux)

...ated nerve damage. New cases of trigeminal neuralgia affect 4 to 5 of every 100,000 people in the United States each year. It affects women slightly more often than men, possibly because the disease is most common in older people and women live longer. The first episode of facial pain usually occurs when the patient is 50 to 70 years old. Although infants, children and young adults may develop this disorder, it is rare in people younger than age 4...

Patient Basics: Subdural Hematoma

...al Info National Institute of Neurological Disorders and Stroke P.O. Box 5801 Bethesda, MD 20824 Phone: 301-496-5751 Toll-Free: 1-800-352-9424 TTY: 301-468-5981 http://www.ninds.nih.gov/ Allergy & Asthma Network Mothers of Asthmatics (AANMA) 2751 Prosperity Ave. Suite 150 Fairfax, VA 22031 Toll-Free: 1-800-878-4403 Fax: 703-573-7794 http://www.aanma.org/ American Association of Neurological Surgeons 5550 Meadowbrook Drive Rolling Meadows, IL 60008...

Patient Basics: Eye Socket Fracture (Fracture Of The Orbit)

...In most cases, swelling and discoloration begin to go away within seven to 10 days after the injury, but fractured bones take much longer to heal. If surgery is necessary to repair the injured area, your doctor may delay the procedure for several weeks to allow swelling to go away. Prevention Almost all eye injuries can be prevented. To decrease your risk of fracturing your eye socket: Use appropriate protective eyewear while working. Studies have...

U.S. firearm fatality rates differ by state, race, and ethnicity

...ational firearm-related fatality (FRF) rate peaked in 1993 at 15 deaths per 100,000 for a total of 39,595 total firearm deaths. Since the early 2000s, the FRF rate has been stable around 10 deaths per 100,000. This study examines state-level differences in the FRF rate, which can be expected given differences in gun control laws and demographics, between 2000 and 2010. The overall national FRF rate was found to be stable with no significant change...

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