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2 Minute Medicine Rewind February 15, 2021

...Approximately 44% had HbA1C levels in the diagnostic range and 59% had IFG, and 73% met either the IFG or HbA1C criteria – 29% met both criteria. Those with prediabetes based on HbA1C at baseline, 9% progressed to diabetes. A total of 13% regressed to normoglycemia and 19% passed away. Of participants with baseline IFG, 8% progressed to diabetes, while 44% regressed to normoglycemia and 16% passed away. Of participants who did not have prediabete...

2 Minute Medicine Rewind June 1, 2020

...7 days before or 30 days after surgery, significant mortality was observed, and perioperative pulmonary complications occurred in more than half the patients. Evidence Rating: 2 (Good) Current guidelines regarding the management of surgical patients during the SARS-CoV-2 pandemic are based solely on expert opinion rather than systematic investigation. With spread to the majority of countries worldwide and significant burden in North America, the...

2 Minute Medicine Rewind April 20, 2020

...Variability in BP measurements are commonly observed and clinical practice, and recent literature has suggested that increase in variability is independently associated with greater cardiovascular disease (CVD) risk and heart failure. In this retrospective cohort study, researchers used the data of 2400 patients from the Coronary Artery Risk Development in Young Adults (CARDIA) study to expand upon prior literature and investigate the association...

2 Minute Medicine Rewind January 3, 2021

...t for newly diagnosed GBM includes surgical resection, concurrent radiation, and temozolomide with subsequent adjuvant temozolomide. Carboplatin is highly effective in treating other malignancies. However, while gliomas have been shown to be sensitive to this anti-cancer drug, using carboplatin has been limited by its systemic toxicity and its inability to penetrate the blood-brain barrier at effective concentrations. In this open-label, nonrandom...

2 Minute Medicine Rewind March 30, 2020

...1 in 5 environmental conditions (aerosols, plastic, stainless steel, copper, and cardboard). The virus was most viable on plastic and steel, with half lives of 6.8 and 5.6 hours, respectively. Viable virus was found up to 72 hours post application on plastic and up to 48 hours on steel. A shorter half-life was recorded for cardboard and copper, measuring in at 3.6 and 0.8 hours, respectively. No viable viruses were detected 24 hours post applicati...

2 Minute Medicine Rewind October 19, 2020

...se, chronic liver disease, cardiopulmonary bypass duration, RBC transfusion, and hypoproteinemia. 3. Risk factors associated with in-hospital mortality for patients with AKI included AKI stage, lactic acidosis, CRRT, and deep hypothermic circulatory arrest. Evidence Rating Level: 2 (Good) Acute kidney injury (AKI) is a common complication after cardiac surgery. Particularly following surgical treatment for acute type A aortic dissections (AAAD), a...

Height and BMI trajectories in children and adolescents are highly variable across the global...

...he quality of nutrition and living environment during early life, childhood, and adolescence. Having low height and excessively low BMI are both measures associated with increased morbidity and mortality. In contrast, high BMI is associated with increased risk of disability and premature death in adulthood. To date, much of the current research on global health and nutrition has focused on the period from preconception to 5 years of age with few s...

2 Minute Medicine Rewind August 17, 2020

...maternal iodine intake associated with subfecundity, reduced foetal growth, and adverse pregnancy outcomes in the Norwegian Mother, Father and Child Cohort Study 1. Low iodine intake associated with decreased subfecundity, reduced fetal growth, increased preterm delivery, and increased preeclampsia. Evidence Rating Level: 2 (Good) The thyroid gland is important in fertility for females and improper functioning has been shown to have adverse effec...

2 Minute Medicine Rewind July 20, 2020

...t elevated cTNI (71.2% vs 6.6%, p<0.001). Even after adjusting for age, sex, and usage of QT-prolonging medications, both initial (per 10-fold increase, HR 1.32, 95% CI 1.06-1.66) and peak cTNI levels (per 10-fold increase, HR 1.70, 95% CI 1.38-2.10) during hospital stay were associated with poor survival. Furthermore, peak cTNI levels were an independent predictor for needing invasive ventilatory support (OR 3.02, 95% CI 1.92-4.98). As well, 53 a...

2 Minute Medicine Rewind July 27, 2020

...Barrett’s Esophagus (BE) is the sole known lesion to be a precursor for EAC, and factors such as for obesity, use of tobacco, and gastroesophageal reflux disease (GERD) have been identified as associated risk factors. Currently however, the association between tonsillectomy and development of EAC is not well characterized, despite these procedures being relatively common and previously associated with greater risk for several diseases, including d...

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