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2 Minute Medicine Rewind July 26, 2021

...ide effects from their treatments. However, patients are tasked with determining whether their symptoms are severe enough to report to their doctors. This can lead to underreporting of adverse side effects, which can have consequences for patient safety, quality of life, and health costs. Remote monitoring is a proposed solution, as patient’s symptoms can be communicated to doctors as quickly as possible. The current randomized controlled trial ev...

2 Minute Medicine Rewind November 16, 2020

...oughout Belgium, Denmark, Italy, the Netherlands, Slovenia, and Great Britain. The study population consisted of 1,130 patients with advanced lung or colorectal cancer, with 685 in the control group and 445 in the intervention: Hospitals were randomized into groups, instead of individual patients. The intervention group patients had conversations with physicians certified in ACP, and also received ACP leaflets. The control group had no changes mad...

2 Minute Medicine Rewind Jan 25, 2021

...for Disease Control and Prevention, US census data, and data from Weedmaps.com on storefront dispensary operations were analyzed by county from 2014-2018, a period of considerable change in cannabis legalization in the country. Models included controls for whether a state allowed for recreational sales and what kinds of opioid interventions (ie naloxone access) were available. As opioid-related mortality rates have recently been largely driven by...

2 Minute Medicine Rewind March 29, 2021

...ng their originally assigned treatment, to a median follow-up of 1.88 years.For the composite primary endpoint, fewer fatal and nonfatal cardiovascular events occurred in either rivaroxaban arm compared to the VKA arm (rivaroxaban vs VKA: HR 0.41, p=0.0006, rivaroxaban and K2 vs VKA: HR 0.34, p=0.0003). While death from any cause, cardiac death, and stroke risk were not significantly different between treatment arms, symptomatic limb ischemia occu...

#VisualAbstract: Upadacitinib plus topical corticosteroids is safe and effective for moderate-to-severe atopic dermatitis;

...erated, with severe adverse events reported for <1% of the study population. Common adverse effects included acne, nasopharyngitis, and upper respiratory infection. The results of this trial demonstrate the efficacy and safety of two doses of Upadacitinib plus topical corticosteroids for the treatment of atopic dermatitis, encouraging future studies on Upadacitinib-based steroid-sparing treatment regiments. Click to read the study in The Lancet Re...

Upadacitinib plus topical corticosteroids is safe and effective for moderate-to-severe atopic dermatitis

...erated, with severe adverse events reported for <1% of the study population. Common adverse effects included acne, nasopharyngitis, and upper respiratory infection. The results of this trial demonstrate the efficacy and safety of two doses of Upadacitinib plus topical corticosteroids for the treatment of atopic dermatitis, encouraging future studies on Upadacitinib-based steroid-sparing treatment regiments. Click to read the study in The Lancet Re...

2 Minute Medicine Rewind February 8, 2021

...nked to lower patient satisfaction and greater risk of prosthesis infection. In fact, 25% of TKR procedures are classified as “likely inappropriate”, underlying the need for alternative knee OA treatments. A procedure known as high tibial osteotomy (HTO) has been used to postpone the need for a TKR, although it is not commonly performed in Canada. In this single-center prospective cohort studies, researchers aimed to quantify the conversion time f...

2 Minute Medicine Rewind April 6, 2020

...s of mortality, with as many as a third of patients reaching fatal outcomes. In the context of sepsis, treatments traditionally used for tachyarrhythmias are often ineffective or contraindicated, leading to a small selection of effective treatment strategies. Past studies have shown landiolol, an ultra-short-acting β1-blocker to be an effective rate control agent in the context of sepsis-related tachyarrhythmias, but no randomized controlled trial...

2 Minute Medicine Rewind March 8, 2021

...ar of admission (71.6% for GI bleed, and 45.6% for intracranial hemorrhage). For all categories of bleed, there was a lower rate of thrombosis for those who resumed OACs (10.0% vs 14.9%, adjusted hazards ratio 0.60, 95% CI 0.50-0.72). However, the rates of bleeding were higher in those who resumed OACs (35.2% vs 16.4%, adjusted HR 1.88, 95% CI 0.48-0.60). Additionally, there was a lower rate of mortality for those who resumed OACs (31% vs 54%, adj...

2 Minute Medicine Rewind April 26, 2021

...literature, the short-term risks of therapies are not as well characterized. In this population-based cohort study, data from medical claims records and prescription data from the National Health Insurance Research Database from January, 2013 to December, 2017 was used to further explore the adverse events and potential risks of corticosteroid bursts, defined as treatment courses of 14 or fewer days. 1,064,587 participants younger than 18 years wh...

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