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#VisualAbstract: Upadacitinib plus topical corticosteroids is safe and effective for moderate-to-severe atopic dermatitis;

...dence Rating Level: 1 (Excellent) Study Rundown: For patients with moderate-to-severe atopic dermatitis (eczema), topical corticosteroids combined with systemic therapy is typically the first line treatment regimen. Upadacitinib is an oral JAK inhibitor used to treat immune-mediated inflammatory conditions that is currently being investigated for the treatment of atopic dermatitis. This randomized, double-blind, placebo-controlled, phase 3 clinica...

Upadacitinib plus topical corticosteroids is safe and effective for moderate-to-severe atopic dermatitis

...dence Rating Level: 1 (Excellent) Study Rundown: For patients with moderate-to-severe atopic dermatitis (eczema), topical corticosteroids combined with systemic therapy is typically the first line treatment regimen. Upadacitinib is an oral JAK inhibitor used to treat immune-mediated inflammatory conditions that is currently being investigated for the treatment of atopic dermatitis. This randomized, double-blind, placebo-controlled, phase 3 clinica...

2 Minute Medicine Rewind March 8, 2021

...c vein in DP procedures. There were 316 patients overall (159 in the intent-to-treat separate division, 157 in the intent-to-treat combined division), with procedures done in 45 institutions in Japan between 2016 and 2019. The primary outcome measured was the incidence of grade B/C PF. In the separate division group, the incidence was 27.1% (42 patients), compared to 28.6% (44 patients) in the combined division (odds ratio 1.108, 95% CI 0.847-1.22...

2 Minute Medicine Rewind April 6, 2020

...effective treatment strategies. Past studies have shown landiolol, an ultra-short-acting β1-blocker to be an effective rate control agent in the context of sepsis-related tachyarrhythmias, but no randomized controlled trials have been completed to further investigate its efficacy and safety. In this multicenter, open-label randomized controlled trial, 151 patients admitted to 54 different hospitals in Japan between 2018 to 2019 were recruited to a...

2 Minute Medicine Rewind February 8, 2021

...after discontinuing treatment.   Pregnancy outcomes in women with moderate-to-severe psoriasis 1. Pregnant women using biologic treatments for psoriasis, both before and during pregnancy, were found to have similar pregnancy outcomes as the general American population. Evidence Rating Level: 2 (Good) Psoriasis is a chronic inflammatory skin disease affecting 7 million adults in the United States. It has been hypothesized that the chronic inflamma...

2 Minute Medicine Rewind April 26, 2021

...fluenza B (FluB), and respiratory syncytial virus. Over the past year, stay-at-home orders, reducing non-essential activities, and wearing of masks amongst other measures have been used to reduce the transmission potential of the novel coronavirus (COVID-19). Interestingly, there is evidence suggesting that these measures have additionally significantly reduced the transmission of other respiratory tract infections. To further investigate this, th...

2 Minute Medicine Rewind September 20, 2021

...A1C (HbA1C), estimated glomerular filtration rate (eGFR), and urine albumin-to-creatinine ratio. The study analyzed the proportions of patients 18 months before the intervention and 18 months after, that went through laboratory testing, received medication prescriptions, and visited primary care or nephrology. In total, 353 children were screened, with 334 having data utilized in the study. 648 control patients were identified, matched by age, sex...

2 Minute Medicine Rewind July 20, 2020

...tion. Evidence Rating Level: 2 (Good) Reports show that patients with COVID-19-associated pneumonia and cardiac injury experience poor outcomes, but whether they were discharged or died remained uncharacterized as the pandemic was ongoing. Additionally, the arrhythmia burden in those admitted to the ICU was estimated at 44.4%, but the nature of these arrhythmias was also largely unknown. Studying data from the Wuhan outbreak, which had run its ful...

2 Minute Medicine Rewind January 11, 2021

...ump in the throat, continuously clearing the throat, and general throat discomfort. As well, gastroesophageal reflux disease (GERD) affects 20% of the Western world, and is often linked to throat and voice symptoms. As a result, treatments for GERD such as proton pump inhibitors (PPIs) have become commonly prescribed for persistent throat symptoms, without sufficient evidence for their efficacy. In this double-blind, randomized controlled trial ex...

Special Rewind: Psychedelics Edition. May 10, 2021

...ated with the magnitude of decline in use.[ 9 ] The synthetic 2,5-dimethoxy-4-iodoamphetamine (DOI), a psychedelic associated with significant mood improvements, also demonstrates effectiveness in reducing alcohol consumption via 5-HT2A alterations. Further, the effects of DOI were associated with alcohol-preferring participants compared to controls.[ 10 ] The culmination of this literature, although incomplete, appears to suggest that psychedelic...

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