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Delayed endovascular thrombectomy associated with greater clinical benefit among patients with mismatch imaging profiles...

...deficit and infarct In-Depth [randomized controlled trial]: This pooled analysis of 6 RCTs as part of the AURORA (Analysis of Pooled Data from Randomized Studies of Thrombectomy More Than 6 Hours After Last Known Well) Collaboration collectively enrolled 505 eligible patients. Among them, 266 (mean [SD] age, 68.4 [13.8] years; 146 women [54.9%]) were assigned to the EVT cohort and 239 (mean [SD] age, 68.7 [13.7] years; 126 men [52.7%]) were assign...

Survey finds high rates of childhood abuse among transgender adolescents

...the sex assigned at birth. Although these health disparities have been widely reported, psychosocial contributors to them have yet to be investigated. This study investigated childhood abuse as a potential psychosocial contributor to mental health difficulties for transgender adolescents as compared to cisgender adolescents, across multiple subgroups of gender identity. Rates of psychological, physical and sexual abuse were higher among transgende...

Gluten intake in females without celiac disease is not associated with cognitive function

...tatus, and history of diabetes, hypertension, and hypercholesterolemia mostly yielded null results. Lastly, changes in gluten intake pattern during study period was also not associated with cognitive scores. Overall, this large-sized, long-term cohort study suggests that gluten intake is not associated with cognitive impairment in women without celiac disease. However, there is limit in generalizability of these results, and further studies with l...

Reduced physical activity from COVID-19 related restrictions may be linked to higher stress and...

...ignificant after controlling for age and sex, as older twins were more likely to report lower anxiety levels and females more likely to report higher anxiety levels (b = 0.150, SE = 0.106, p = 0.158). Overall, decreased perceived physical activity was linked to higher stress and anxiety, although the association with stress was confounded by genetics and shared environment, and anxiety with age and sex. This study demonstrates that the restriction...

Rustbelt states may have greatest racial disparities between black and white men for firearm...

...e males have a greater risk than black males for firearm suicides, especially in Alabama, Arkansas, Mississippi, Nevada, and New Mexico. Evidence Rating Level: 4 (Below Average) Study Rundown: Although it is known that there are racial disparities in deaths from violence, it is unknown if these disparities differ by state and to what extent they differ. In this surveillance study, researchers compared the rates between states for homicide and suic...

Wellness Check: Nutrition

...tatus, and history of diabetes, hypertension, and hypercholesterolemia mostly yielded null results. Lastly, changes in gluten intake pattern during study period was also not associated with cognitive scores. Overall, this large-sized, long-term cohort study suggests that gluten intake is not associated with cognitive impairment in women without celiac disease. However, there is limit in generalizability of these results, and further studies with l...

Abusive head trauma results in fewer productive life-years

...mild. The value of estimated mean lifetime loss per case in 2009 was 4.7 DALYs for minor AHT, 5.4 DALYs for moderate AHT, and 24.1 DALYs for severe AHT. The estimated burden of AHT incidence in 2009 was 0.017 DALYs per live birth in the United States. More from this author: Childhood ADHD, stimulant treatment not linked with height, Healthcare-associated infections falling among critically ill children, Postresuscitation care may be needed regardl...

Improved glycemic control in type 1 diabetics on very low-carbohydrate diets

...also sought. Out of 316 participants (57% female, 42% children) in the analysis, only 138 had follow-up medical survey data gathered. The mean amount of time participants committed to this lifestyle was 2.2 + 3.9 years. A total of 97% of participants in the study met national guidelines with regards to the ideal glycemic range, defined as HbA1c <7.5% for children and <7% for adults. On average, HbA1c decreased by 1.45% + 1.04% (p < 0.001), as rep...

#VisualAbstract: BNT162b2 mRNA vaccine shows benefit against symptomatic and asymptomatic SARS-CoV-2 infection

...and age < 35 (aOR 0.78, 95% CI 0.64-0.96) were associated with significantly lower vaccine coverage. Compared to the vaccinated group, the unvaccinated group reported a substantially greater number of new infections (71 cases vs. 977 cases) during follow-up (adjusted hazard ratio 0.30, 95% CI 0.15-0.45). In the unvaccinated cohort, 543 (56%) patients had typical COVID-19 symptoms and 140 (14%) were asymptomatic 14 days prior to PCR-positive resul...

David H. Roberts, MD

...nt responsibilities include developing innovative educational programs for online learning, lay education, continuing medical education and executive education for learners across the globe. He has served on national education committees and as an editor for the education sections of medical journals. View the Complete Editorial Staff EDUCATION >> Massachusetts General Hospital (Fellowship) >> Massachusetts General Hospital (Residency) >> Harvard...

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