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AstraZeneca coronavirus vaccine rarely causes immune thrombotic thrombocytopenia
...-linked immunosorbent assay (ELISA) with an optical density greater than 3.00 units (reference value, <0.50). Using platelets derived from healthy donor whole blood, a platelet activation assay was performing using four of the serum samples from the thrombotic patients. The platelet activation assay showed increased reactivity in the presence of PF4, independent of heparin, and inhibition with low molecular weight heparin or intravenous immune glo...
2 Minute Medicine Rewind January 3, 2021
...e, observational, single-centre study, 176 patients taking either aspirin 100 mg daily, aspirin 300 mg daily, or clopidogrel 75 mg daily with symptomatic PAD (peripheral arterial disease) or internal carotid stenosis were included. They had the activity of their antiplatelet medication measured by impedance aggregometry (using Multiplate®) before and after their vascular procedure. Prior to vascular treatment, prevalence rates of ALR and CLR were...
2 Minute Medicine Rewind February 22, 2021
...hird. The overall infection rate in pregnancy among trial sites was 13.9/1,000 deliveries. When comparing this to the overall infection rate among those aged 20-39 years in Washington State (7.3/1,000), the infection rate in pregnancy was a significant 1.7 times higher. Furthermore, when compared with those who delivered live births in Washington State in 2018, the proportion of infections in pregnancy among most racial and ethnic minority groups...
2 Minute Medicine Rewind April 12, 2021
Effect of high-frequency (10-kHz) spinal cord stimulation in patients with painful diabetic neuropathy 1. Pain relief and health-related quality of life was significantly improved among those undergoing 10-kHz spinal cord stimulation, compared to conventional medical management. 2. Outcomes in pain relief were sustained through the six-month follow-up. Evidence Rating Level: 1 (Excellent) The global prevalence of diabetes is approximately 8.5% an...
2 Minute Medicine Rewind February 15, 2021
...5.7% and 6.4% and impaired fasting glucose (IFG) level was an FG level of 100-125mg/dL. The main outcome of this study was incident total diabetes. Of the 3,412 initial participants without diabetes, 2,497 attended follow-up or passed away. Over the course of the 6.5 years, there were 156 incident total diabetes cases and 434 deaths. Approximately 44% had HbA1C levels in the diagnostic range and 59% had IFG, and 73% met either the IFG or HbA1C cri...
2 Minute Medicine Rewind January 25, 2021
...including a reduction in 24-hour urinary frequency from 11.3 to 9.9 (p < 0.0001); a decrease in mean maximum urgency rating from 2.5 to 2.2 points (p < 0.0001); and a decrease in mean nocturia from 2.1 to 1.8 nightly episodes (p < 0.001). Furthermore, the mean total AUA-7 SI score – a standardized questionnaire tracking storage symptoms (urgency, frequency, and nocturia) that most often map to OAB and voiding symptoms (hesitancy, weak stream, feel...
2 Minute Medicine Rewind January 11, 2021
...and disseminated intravascular coagulation (absolute risk ranging from 0.1-0.4%). Overall, this study demonstrated identified several complications associated with COVID-19, which can help inform patient management and treatment decisions for COVID-19 patients. Psychological impacts from COVID-19 among university students: Risk factors across seven states in the United States 1. During the COVID-19 pandemic, 45.2% of college students experience...
2 Minute Medicine Rewind January 18, 2021
...), a disease-nonspecific marker of neuronal injury. Data between February 2007 and June 2016 from the Alzheimer’s Disease Neuroimaging Initiative was used. Further, follow-up blooding sampling was performed for up to eight years and plasma p-tau181 measurements were performed in 2020. Participants were eligible if they had available plasma p-tau181 and NfL measurements as well as at least one FDG PET or MRI scan at the same study visit. Significan...
2 Minute Medicine Rewind March 29, 2021
...GUIDE‐IT trial 1. In both obese and non-obese patients, NT-proBNP level <1000pg/mL during treatment showed favourable prognostic implications in heart failure with reduced ejection fraction. Evidence Rating Level: 2 (Good) While obesity itself is a major risk factor for developing heart failure, overweight and obese patients have been reported to have paradoxically better prognoses in heart failure compared to normal and underweight patients. N-t...
2 Minute Medicine Rewind March 1, 2021
..., who were hospitalized at least once for HF in the last five years , and 300 cardiologists was collected. These patients (median age of 69 years, 69.3% male) included both inpatients and outpatients with acute and chronic heart failure. In total, only 38.1% of patients were tested, and 33.9% were diagnosed with ID. Of those diagnosed, 46.2% received iron supplementation (76.2% intravenously, 23.8% orally). In patients with HFrEF diagnosed with ir...
