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Quick Take: Low rates of specialized cancer consultation and cancer-directed therapy for noncurable pancreatic...

...ncurative pancreatic adenocarcinoma in Ontario, Canada, between the years 2005 and 2016 were followed up to examine patterns and factors associated with access to specialized cancer care and receipt of cancer-directed therapy in this patient population. With a median age at diagnosis of 72 years (IQR 62 to 80 years), median survival was reported to be 3.3 months (IQR 1.2 to 8.5 months). Researchers found that 26.6% of patients received systemic ch...

Do higher doses help? Infant bone health similar despite varying Vitamin D doses

..., in any of the different Vitamin D dosage groups, including the standard 400IU supplementation group. 2. It remains unknown if non-bone health benefits may arise from Vitamin D supplementation in excess of 400IU daily. Evidence Rating Level: 2 (Good) Study Rundown: Vitamin D supplementation is required in breastfed infants, as necessary amounts are not provided in breastmilk. For this reason, 400 IU supplementation is recommended daily, as it has...
Classics Series, Landmark Trials in Medicine

The CARE trial: Statins in coronary artery disease [Classics Series]

...ation, were between 21-75 years of age, had total cholesterol levels of <240 mg/dL, had LDL cholesterol levels between 115-174 mg/dL, had fasting triglyceride levels <350 mg/dL, had fasting glucose levels <220 mg/dL (12.2 mmol/L), had left ventricular ejection fractions of ≥25%, and did not have symptomatic congestive heart failure. Patients were randomized to receive pravastatin 40 mg daily or placebo, and were followed for a median of 5.0 years....

2 Minute Medicine Rewind May 19 – May 26, 2014

...n (6kg gain vs 3.8kg weight loss in the haloperidol group at 24 months, p<.001) and higher prolactin levels, while those receiving haloperidol reported more severe akathisia (p=.006) but similar degrees of abnormal involuntary movements, parkinsonism, and tardive dyskinesia. Similar to other recent analyses, this study found that long-acting injectable paliperidone palmitate, an atypical antipsychotic, had similar efficacy compared to the older-ge...

Mental health in young adults may be linked to sleep chronotype

...es recorded higher depression and anxiety scores, and poorer sleep quality in comparison to morning and intermediate chronotypes. 2. Positive psychological traits, such as mindfulness and positive social interactions, were more frequently reported by individuals with morning chronotypes. Evidence Rating Level: 2 (Good) Circadian rhythm preferences, also known as chronotypes, impact physical and mental performance. Previous studies have found an as...

2 Minute Medicine Rewind June 24 – June 30

...and aspirin had a decreased rate of ischemic strokes (7.9% vs. 11.4%, p<0.001) and an equal rate of hemorrhagic strokes (0.3% each). There was no statistically significant difference in hemorrhagic events or adverse drug effects. Contribution of Preventable Acute Care Spending to Total Spending for High-Cost Medicare Patients In this retrospective cohort analysis, investigators looked at Medicare records and identified patients in the top decile...

Children who follow dietary, physical activity, sleep recommendations have fewer mental health visits

...tions, after adjusting for sex, body weight, parental education, household income, and region of residence. Each additional recommendation met was associated with 15% (95% CI: 9%-21%) fewer mental health visits in the subsequent 4 years. Image: PD ©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed a...

James Gray, MB

...ersity of Minnesota Pediatrics Program James has lived all over the world, including the UK, Portugal, three US states, Canada, and Ireland. He loves to travel and has interests in critical care, cardiology and global health pediatrics. In rare moments when not at work, he enjoys long bike rides and short espressos. View the Complete Editorial Staff EDUCATION >> University of Minnesota (Residency) >> University College Dublin Medical School >> Que...

Carboplatin during radiotherapy recommended exclusively in pediatric patients with high-risk group 3 medulloblastoma

...ears [range, 3.3-21.2]; 183 [70%] male). Data was collected between March 2007 and September 2018 from Children’s Oncology Group institutions with analysis completed in September 2020. High-risk features included metastasis (189 patients [72%]), diffuse anaplasia (58 patients [22%]), and greater than 1.5-cm2 residual disease (14 patients [5%]). For interventions, patients were randomized to receive 36-Gy craniospinal radiation therapy and weekly v...

The DIG trial: Digoxin associated with significant decrease in hospitalizations in patients with systolic...

...hed in NEJM in 1997. This landmark randomized controlled trial enrolled 6,800 patients and sought to examine the long-term effects of digoxin on mortality and hospitalization in patients suffering from systolic heart failure. Relevant Reading: Lee DC, Johnson RA, Bingham JB, et al. Heart failure in outpatients: A randomized trial of digoxin versus placebo. N Engl J Med 1982;306:699-705. Uretsky BF, Young JB, Shahidi FE, et al. Randomized study ass...

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