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Colchicine safe and effective for recurrent pericarditis [CORP-2 trial]

...e also reduced the symptom persistence at 72 hours, recurrences per patient, and pericarditis-related hospital admissions. There were no serious adverse effects. Evidence Rating Level: 1 (Excellent) Study Rundown: Low-dose colchicine has been shown to be safe and effective for treating acute pericarditis and the first recurrences of pericarditis. Current treatment for multiple recurrences generally consists of immunosuppressive therapies which can...

Patient Basics: Squamous Cell Carcinoma of the Skin

...sing agents. This type of squamous cell cancer can develop on: Scars, burns, and long-lasting ulcers The legs and body of workers exposed to poisons, harsh chemicals, and agents like tar and soot Skin affected by genital warts Red patches of skin covered with white scales, a condition called psoriasis, treated with certain therapies. People with a weakened immune system are at especially high risk of developing squamous cell cancer. This includes...

Patient Basics: Polio

...tis (also called abortive poliomyelitis) occurs primarily in young children, and is the more common of the two forms. The illness is mild, and the brain and spinal cord are not affected. Symptoms appear three to five days after exposure to the virus and include slight fever, headache, sore throat, vomiting, lack of appetite, and a general feeling of illness and discomfort. Major poliomyelitis is a more severe illness that develops approximately 7...

Patient Basics: Vaginal Cancer

...lloma virus (HPV) infections. HPV infection can also lead to cervical, anal, and throat cancers. Less common types of vaginal cancer include malignant melanomas and sarcomas. Melanomas tend to affect the lower or outer part of the vagina. Sarcomas develop deep in the vaginal wall. Symptoms Symptoms of vaginal cancer include: abnormal vaginal bleeding, often after sex, that is not related to your period unusual vaginal discharge a mass that can be...

A word on stats [Perspective]

...alysis rests on the mathematical description of uncertainty and probability, and we grapple with these concepts most clearly in a pair of dice. It is no surprise, therefore, that just as teachers now ease into statistics with decks of cards and buckets of balls, the mathematics of statistics was invented to explain games of chance. What is surprising and somewhat mysterious is that humans have been throwing dice and casting lots for millennia, but...

Patient Basics: Head Lice

...em to grasp and wander between hairs. They feed only on the blood of people, and feed once or more each day. They are more common on children than adults. A single insect is called a louse. A female louse can lay more than 100 eggs, called nits, in her lifetime. The female louse secretes a glue to attach each egg to a scalp hair, usually close to scalp level. They hatch about 8 days after they are laid, and grow to the adult stage about 9 to 12 da...

Silicon microparticles may improve chemotherapeutic delivery to metastatic tumors in mice [PreClinical]

...ion revealed preferential iNPG-pDox localization to lung tumor microvessels, and flow cytometry analysis showed a higher percentage of Dox-positive endothelial (p<0.05) and lung tumor cells (p<0.01) in the iNPG-pDox treatment group as compared to free Dox or liposome-encapsulated Dox (Doxil). Biweekly 6 mg/kg iNPG-pDox treatment also resulted in a median survival time of 233 days as compared to 84-124 days in other treatment groups (p<0.01 vs. fre...

Phase II trial reports leukemia remissions using engineered T cell therapy

...(95% CI, 65 to 95). All patients experienced the cytokine-release syndrome, and 27% developed a severe reaction. More from this author: Early risk factor for progression of cystic fibrosis identified, Gut microbes implicated in stroke and heart attacks: new dietary link, New leukemia mutation offers therapeutic targets, Childhood ADHD associated with increased risk of suicide, A marker of aggressive liver cancer and potential therapeutic target i...

Patient Basics: Chronic Lymphocytic Leukemia (CLL)

...e of white blood cell. CLL usually grows slowly compared to other leukemias, and it may not cause symptoms for some time. CLL is one of four main types of leukemia. It is the second most common type of leukemia in adults; most people with CLL are middle-aged or older. The disease is very rare in children. Normally, a person’s immature blood stem cells develop into myeloid and lymphoid stem cells. The myeloid cells become mature blood cells: white...

Infectivity of SARS-CoV-2 in children compared with adults

...ere not as likely to grow in culture, had higher cycle thresholds in RT-PCR, and had lower viral concentrations, compared to adult specimens. Evidence Rating Level: 2 (Good) Although the pediatric population is a substantial driver of common viral transmissions, such as the flu, there is conflicting evidence surrounding the extent of their role in COVID-19 transmissions. For instance, some studies have shown higher viral loads in children, whereas...

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