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Patient Basics: Pancreatic Cancer

...on many things: how much the cancer has spread, your age and general health, and how well your body responds to treatment. Prevention There is no proven way to prevent pancreatic cancer. You can decrease your risk of getting this cancer by not smoking. Cigarette smoking is the most significant risk factor associated with pancreatic cancer. If you smoke, quit. If you don’t smoke, don’t start. Also you may decrease your risk of developing pancreatic...

Patient Basics: Gastritis

...ch lining. The lining of the stomach often looks red, irritated and swollen, and it may have raw areas that can bleed. Many different illnesses and irritants — acting either alone or in combination — can trigger the inflammation of gastritis. Some of the most common triggers include: Infection with Helicobacter pylori (H. pylori) bacteria — In addition to causing gastritis, H. pylori infections have been linked to the development peptic ulcer dise...

Patient Basics: Hodgkin Lymphoma

...twork of immune cells, small blood-vessel-like structures called lymphatics, and lymph nodes. It also includes organs made primarily of immune cells such as the spleen and thymus gland. The lymph (or lymphatic) system helps fights infections and other diseases. The lymph system includes: Lymph: A clear fluid that carries white blood cells (especially lymphocytes) through the lymph system. White blood cells help fight infection. Lymph vessels: A ne...

Active monitoring compared to maintenance capecitabine is a viable alternative for stable metastatic colorectal...

...ring (AM). Secondary outcomes included overall survival (OS), QoL, toxicity, and safety. Capecitabine improved median PFS as compared to AM, while overall survival did not differ significantly. Quality of life was assessed via EQ-5D forms and there were no significant differences in QoL scores. However, discomfort and pain were somewhat increased in the AM group as compared to the treatment group, potentially due to the increased rate of progressi...

Cholesterol-containing lipid particles protect mice from lethal bacterial toxins

...to human pathogens, including particular strains of S. pyogenes, S. aureus, and S. pneumoniae, was dependent on both the specific pathogen and liposomes administered, suggesting that tailored liposome cocktails could be used to sequester multiple toxins released by different bacteria strains. Researchers found that liposome injection within ten hours of a lethal bacterial infection significantly improved mouse survival rates and reduced bacterial...

Continuous infusion of beta-lactams may be superior to bolus therapy

...om the small cohort of patients enrolled, confounding by unmeasured factors, and lack of power to evaluate an effect on survival. However, this study demonstrates the feasibility of performing a larger multicenter trial in an effort to determine the optimal method of administering beta-lactams in critically ill patients. Click to read the study in CID Click to read an accompanying editorial in CID [/tab] [tab] Image: PD 1. Continuous infusion of b...

Upadacitinib plus topical corticosteroids is safe and effective for moderate-to-severe atopic dermatitis

...the study population. Common adverse effects included acne, nasopharyngitis, and upper respiratory infection. The results of this trial demonstrate the efficacy and safety of two doses of Upadacitinib plus topical corticosteroids for the treatment of atopic dermatitis, encouraging future studies on Upadacitinib-based steroid-sparing treatment regiments. Click to read the study in The Lancet Relevant Reading: Upadacitinib in adults with moderate to...

Quick Take: Overall survival with ribociclib plus endocrine therapy in breast cancer

...E011’s [Ribociclib’s] Efficacy and Safety-7 (MONALEESA-7), an international, randomized, double-blind placebo-controlled phase III trial, researchers compared ribociclib versus placebo in addition to endocrine therapy with goserelin and either a nonsteroidal aromatase inhibitor or tamoxifen, in women age 18 to 59 years with histologically or cytologically confirmed hormone receptor-positive, HER2-negative advanced breast cancer. Overall survival w...

2 Minute Medicine Rewind September 3, 2018

...was found with respect to safety when comparing the two doses of tafamidis, and permanent discontinuation of treatment due to adverse events occurred less frequently in the tafamidis group than the placebo group. Taken together, the results of this study suggest that tafamidis may have a role in treating transthyretin amyloid cardiomyopathy, although further investigation with administration earlier during the disease course could better characte...

Patient Basics: Pyelonephritis

...tis are pain in one flank, the area just beneath the lower ribs in the back, and fever. The pain can travel around the side toward the lower abdomen. There also can be shaking chills and nausea and vomiting. The urine may be cloudy, tinged with blood or unusually strong or foul-smelling. You may need to urinate more often than normal and urinating may be painful or uncomfortable. Diagnosis If your doctor is concerned that you have a kidney infecti...

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