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Bariatric surgery not associated with hypothesized reduction in opioid use

...ication decreases rates of criminality in ADHD patients, Low dose aspirin shows net clinical benefit in patients with first unprovoked venous thromboembolism, Rare TREM-2 mutation implicated in Alzheimer’s Disease © 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post shou...

Lateral foot wedges not effective in medial knee osteoarthritis pain control

...knee of osteoarthritis patients. In this analysis, the lateral wedge was shown to decrease pain when compared to using no wedge but did not significantly reduce pain when compared to a neutral wedge. One limitation to this analysis is that only a small number of randomized control trials (RCTs) were included in the final meta-analysis. Furthermore, the meta-analysis is inherently limited by biases within each of the included studies, including th...

Patient Basics: Alcohol Withdrawal

...sumed enough alcohol to damage other organs. It is a good idea for your doctor to examine you carefully and do blood tests, checking for alcohol-related damage to your liver, heart, the nerves in your feet, blood cell counts, and gastrointestinal tract. Your doctor will evaluate your usual diet and check for vitamin deficiencies because poor nutrition is common when someone is dependent on alcohol. It is usually difficult for people who drink to b...

#VisualAbstract: Ticagrelor non-superior to clopidogrel in the reduction of PCI-related myocardial necrosis

...groups at 12 months. Nonetheless, this study provided important insight into the efficacy of ticagrelor to reduce periprocedural myonecrosis after elective PCI. Click to read the study in The Lancet Relevant Reading: Association of Ticagrelor vs Clopidogrel With Net Adverse Clinical Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention In-depth [randomized controlled trial]: Between Jan 9, 2017, and May 28,...

Factors associated with firearm suicide in the United States

...firearm owners had a greater risk of firearm suicide (HR 3.00, 95% CI 2.50 to 4.39) and non-firearm suicide (HR 1.20, 95% CI 0.97 to 1.48) than noncitizens. Risk increased with combinations of these variables. For example, firearm suicide rates were higher among males in high firearm ownership states (19.9 per 100,000 person-years) than the same demographic in states with low firearm ownership (7.9 per 100,000 person-years). For females, firearm s...

Eritoran does not decrease mortality during severe sepsis [The ACCESS Trial]

...eritoran decreases mortality. 2. In this phase III trial, eritoran is not shown to decrease 28-day or 1-year mortality in severe sepsis and septic shock patients. Sepsis is the result of abnormal systemic inflammation, of which lipopolysaccharide (LPS) i.e. endotoxin is a major stimulator. The current standard of care for severe sepsis involves fluid resuscitation and antimicrobial therapy. Eritoran, a synthetic analog of lipid A, acts as a specif...

USPSTF recommends behavioral counseling to reduce cardiovascular disease

...to the 2003 USPSTF recommendation on counseling in adults with CVD risk factors. To formulate this recommendation, the USPSTF assessed 74 trials that reported on counseling effects on health outcomes and intermediate measures of CVD risk (such as blood pressure). Counseling focused on diet, physical activity, or both. Studies were included if participants had at least 1 CVD risk factor, and most patients in these studies were either overweight or...

Longer duration of obesity increases risk of coronary heart disease

...CAC with each additional year of overall obesity or abdominal obesity was shown to be 1.02 (95% CI, 1.01-1.03) and 1.03 (95%CI, 1.02-1.05) respectively. Longer duration of obesity was also associated with higher blood pressure, glucose, C-reactive peptide, and triglycerides. By John Prendergass and Brittany Hasty More from this author: Reducing surgical complications may increase costs, Protected sleep periods improve intern alertness and sleep du...

Restricting perioperative fluid for abdominal surgery patients does not reduce complications: The RELIEF trial

...ed liberally to surgical patients both during and after their procedure in order to maintain adequate tissue oxygenation and urine output. In abdominal surgery, such fluid administration can cause adverse effects like tissue edema and weight gain, which may be associated with longer hospitalizations. At present, there is conflicting evidence regarding whether restrictive or liberal fluid management for patients undergoing major surgery is advised....

#VisualAbstract: Effect of ticagrelor monotherapy vs ticagrelor with aspirin on major bleeding and cardiovascular...

...notherapy with an anti-platelet agent such as Ticagrelor has the potential to be a safer strategy than extended DAPT. However, this study was not blinded and would benefit by expansion to include a more geographically, racially, and gender diverse patient population. Click to read the study, published in JAMA In-Depth [randomized controlled trial]: Following acute coronary syndromes, patients commonly undergo placement of DES, followed by a year o...

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