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#VisualAbstract: Ticagrelor non-superior to clopidogrel in the reduction of PCI-related myocardial necrosis

1. There was no significant difference in periprocedural myonecrosis between ticagrelor and clopidogrel among patients undergoing high-risk elective PCI. 2. Ticagrelor treatment was associated with an increased rate of minor bleeding at 30 days post-operation. Evidence Rating Level: 1 (Excellent) Study Rundown: Percutaneous coronary intervention (PCI) provides a safe therapeutic option for patients with coronary artery disease (CAD). However, per...

Factors associated with firearm suicide in the United States

..., limited information is known regarding the personal characteristics associated with firearm suicide risk. This retrospective cohort study examined respondents from the Mortality Disparities Across Communities study, which linked 2008-2015 National Death Index death records with 2008 American Community Survey data. Firearm suicide rates were found to be highest among those with military background (21.2 per 100,000 person-years), 95% CI 19.4 to 2...

Eritoran does not decrease mortality during severe sepsis [The ACCESS Trial]

...wn” tab2= “2MM Full Report”] [tab] Image: PD 1. Previous phase I and phase II trials in severe sepsis patients show the lipopolysaccharide antagonist eritoran decreases mortality. 2. In this phase III trial, eritoran is not shown to decrease 28-day or 1-year mortality in severe sepsis and septic shock patients. Sepsis is the result of abnormal systemic inflammation, of which lipopolysaccharide (LPS) i.e. endotoxin is a major stimulator. The curren...

Adding trained interventionists to primary care results in weight loss

1. Primary care visits supplemented by sessions with trained interventionists resulted in greater patient weight loss than primary care visits alone. 2. Frequent telephone calls from interventionists may also be successful as a standalone weight loss treatment program. Evidence Rating Level: 1 (Excellent) Study Rundown: The health impacts of obesity are widely recognized by the medical community for some time and include hypertension, type 2 diab...

USPSTF recommends behavioral counseling to reduce cardiovascular disease

...utcomes (such as mortality), it did produce modest improvements in intermediate CVD markers, and was not associated with substantial harms. Evidence Rating Level: 1 (Excellent) Study Rundown: Cardiovascular disease is a significant cause of death and disability in the United States, particularly among adults who are overweight or obese. In this systematic review and resulting guideline, the USPSTF addressed the role of primary care-based counselin...

Longer duration of obesity increases risk of coronary heart disease

...: PD 1. Longer duration of overall obesity and abdominal obesity were associated with higher degree of coronary artery calcification. 2. Delaying the onset of obesity in young adults may lower their risk of developing coronary artery disease in middle age. Evidence Rating Level: 1 (Excellent) Study Rundown: Coronary artery calcification (CAC) is a known risk factor for coronary heart disease events such as myocardial infarctions. While CAC does ta...

Restricting perioperative fluid for abdominal surgery patients does not reduce complications: The RELIEF trial

...ly to surgical patients both during and after their procedure in order to maintain adequate tissue oxygenation and urine output. In abdominal surgery, such fluid administration can cause adverse effects like tissue edema and weight gain, which may be associated with longer hospitalizations. At present, there is conflicting evidence regarding whether restrictive or liberal fluid management for patients undergoing major surgery is advised. The Restr...

#VisualAbstract: Effect of ticagrelor monotherapy vs ticagrelor with aspirin on major bleeding and cardiovascular...

.... 2. At one year, patients who received Ticagrelor alone experienced significantly fewer adverse major bleeding events. There was no reduction in adverse cardiac or cerebrovascular events. Evidence Rating Level: 1 (Excellent) Study Rundown: In an effort to determine whether Ticagrelor monotherapy, as compared to a standard 1-year of DAPT following DES placement reduces the risk of adverse events, a randomized multi-center trial was conducted acros...

Erythropoietin linked with reduced risk of brain injury in preterm infants

...t erythropoietin to premature infants within 42 hours after birth was associated with a decreased risk of brain injury. 2. Analysis of the primary outcome of this study assessing brain development at 2 years of age is pending. Evidence Rating Level: 2 (Good) Study Rundown: Protecting and promoting the neurological development of preterm infants is a challenging task. Erythropoietin, a hormone known to control red blood cell production, has been ad...

Urinary mRNA profiling accurately diagnoses rejection in kidney allografts

...r. Evidence Rating Level: 2 (Good) Study Rundown: Proposed as a method to diagnose acute cellular rejections, urinary mRNA profiling has a significant advantage over the gold standard needle biopsy in that it is non-invasive. Additionally, the diagnostic signature may reveal forthcoming rejection that hasn’t shown up on biopsy yet, which is welcome news to clinicians that manage transplant patients. The downside is also apparent – sensitivity and...

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