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Bariatric surgery associated with sustained improvements in mobility and joint pain

...ho underwent bariatric surgery; either Roux-en-Y gastric bypass (RYGB) or laparoscopic adjustable gastric banding (LAGB), and found that, after 1 year post-surgery, there was an improvement in bodily pain, physical function, joint pain, joint function, and mobility. There were no differences in the results between the type of operation. Three years after the surgery, patients tended to have poorer bodily pain and physical functioning as compared t...

Contraband tobacco leads to reduced smoking cessation

Image: PD 1. Contraband tobacco users are significantly less likely attempt to quit or abstain from smoking. 2. Smoking contraband tobacco is highly associated with heavy smoking, length of smoking history, and perceived addiction. Evidence Rating Level: 2 (Good) Study Rundown: In an effort to reduce tobacco use, Canada has implemented high taxes on tobacco products to provide an economic incentive to quitting. As an unintended consequence this h...

Andrew Cheung, MD MBA

Attending Physician Managing Editor Andrew Cheung, MD MBA Attending Physician, St. Joseph’s Healthcare Hamilton Andrew is responsible for leading the Classics section, which reviews landmark trials in medicine. He is an avid basketball fan and his hometown is Mississauga, Ontario, Canada. He completed his MBA at Northwestern and his MD at uOttawa. View the Complete Editorial Staff EDUCATION >> Attending Physician, St. Joseph’s Healthcare Hamilto...

Quick Take: Risk of rhabdomyolysis with donepezil compared with rivastigmine or galantamine

...risk of hospital admission for rhabdomyolysis compared to rivastigmine or galantamine for Alzheimer’s disease and dementia. Evidence Rating Level: 2 (Good) Regulatory agencies have issued a post-marketing surveillance warning regarding the risk of rhabdomyolysis with donepezil use, commonly used in managing symptoms of Alzheimer’s disease and dementia. The Pharmacovigilance Databases of the United States and Canada data indicated that such events...

2 Minute Medicine Rewind September 23, 2019

...dence Rating Level: 1 (Excellent) While most patients with depression are managed in the primary care setting, there is limited evidence regarding the effectiveness of antidepressants across different severities of illness in the outpatient setting. This is largely due to the narrow eligibility criteria used in studies conducted thus far, specifically concerning the diagnoses and severity of disease in research participants. The PANDA trial examin...

O and Rh– blood groups may be associated with decreased risk for SARS-CoV-2 infection

...ccount for influential confounders. This population-level study that drew data from a universal health care system found that blood groups B and AB had a higher risk of SARS-CoV-2 infection compared to blood group A. Examined as a whole, the non-O group had a significantly higher risk of infection compared to the O group; similarly, the rhesus-positive group had a significantly higher risk of infection compared to the rhesus-negative group. Type O...

Bypass grafting versus stenting for patients with severely reduced ejection fraction

...fraction (LVEF). This retrospective cohort study of patients in Ontario, Canada sought to determine whether or not outcomes differ between with severely reduced LVEF with left main coronary artery, left anterior descending artery, or multivessel disease who undergo percutaneous coronary intervention (PCI) and those who undergo coronary artery bypass grafting (CABG), including all-cause mortality and death from major adverse cardiovascular events...

2 Minute Medicine Rewind April 13, 2020

Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis 1. Sepsis bundles were not significantly associated with decreased risk of mortality or reduced vasopressor treatment time in community- or hospital-onset sepsis. 2. Components of the SEP-1 bundle, such as broad-spectrum IV antibiotic treatment and lactate levels were associated with improved outcomes in this popula...

2 Minute Medicine Rewind November 17 – November 23, 2014

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Glycemic Control and Excess Mortality in Type 1 Diabetes To date, the increase in risk of death from any causes and specifically cardiovascular disease that is attributable to type 1 diabetes has not been reported. In this retrospective analysis, 33,915 Swedish patients with type 1 diabetes, who were registered in the Swedi...

Neuraxial anesthesia associated with decreased 30-day all-cause mortality for patients undergoing lower limb revascularization

...hough endovascular interventions are increasingly common for the surgical management of peripheral artery disease, lower limb revascularization surgeries like endarterectomy and arterial bypass are still frequently performed. This comparative effectiveness study evaluated whether use of neuraxial anesthesia or general anesthesia for patients undergoing lower limb revascularization would be associated with improved clinical outcomes. Patients were...

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