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#VisualAbstract: Nemolizumab for pruritis in atopic dermatitis patients

...e results of the study demonstrated that the addition of nemolizumab significantly reduced the pruritis visual-analogue scale (VAS) score after 16 weeks of treatment. Other measurements of quality of life were also significantly improved with nemolizumab such as improvement in the Eczema Area and Severity Index (EASI), Dermatology Life Quality Index (DLQI), and the Insomnia Severity Index (ISI). The main safety profile difference was an increased...

2 Minute Medicine Rewind July 6, 2020

...ences in Rates of Autopsy In the US, 2008-2017 1. Autopsy rates have significantly declined over time, though the rates of autopsy among Black persons was significantly higher than those among White persons. 2. Among several possibilities, this may illustrate racial health disparities related to precision and extent of diagnostic workups prior to death. Evidence Rating Level: 2 (Good) Clinical autopsy rates have declined over time, potentially due...

#VisualAbstract: Duration of Initial Empirical Antibiotic Therapy and Outcomes in Very Low Birth Weight...

...h weight (VLBW) infants who received antibiotics for 4 to 7 days had significant increased odds of short term morbidity and mortality. 2. Each day of antibiotic use among VLBW infants was associated with about 5% greater odds of major adverse outcomes. Evidence Rating: 2 (Good) Study Rundown: Early onset sepsis (EOS) is a serious problem among VLBW neonates, therefore providers often initiate empiric antibiotics. These medications are usually disc...

Advanced care planning intervention for patients with advanced lung or colorectal cancer

...colorectal cancer. 2. ACP was found to increase the number of patients receiving specialized palliative care, and having advanced directives recorded in hospital files. Evidence Rating Level: 1 (Excellent) Discussions regarding end-of-life plans among patients, family, and healthcare professionals are associated with numerous positive outcomes, such as better emotional functioning, increased symptom resolution, and less demanding interventions. Ad...

Rapid antigen testing for SARS-CoV-2 infection found to have limited accuracy for a pediatric...

...cohort, rapid antigen testing for SARS-CoV-2 infection was found to have limited accuracy when compared with reverse-transcriptase polymerase chain reaction testing. Evidence Level Rating: 2 (Good) Since the start of the COVID-19 pandemic, reverse-transcriptase polymerase chain reaction (RT-PCR) testing performed on nasopharyngeal swabs has been the most widely used means of establishing the presence of infection. The Panbio™ COVID-19 Antigen (Ag...

#VisualAbstract: Serum antibody testing for SARS-CoV-2

...ed the SARS-CoV-2 spike protein serum assay’s ability to present antibody kinetics and subsequent clinical use. Results from antibody testing were able to provide diagnostic patient support when patients had tested negative through NAAT but remained at clinical suspicion for COVID-19. This case-control study was limited by its sampling of hospitalized patients. The convenience sampling in the study created a bias since patients who were asymptomat...

Association of potent topical corticosteroids and the risk of osteoporosis and major osteoporotic fractures

..., exposure (≥ 500 g vs. 200-499 g) to potent or very potent TCSs was significantly associated with an increased risk of both osteoporosis (HR 1.08, 95% CI 1.05 to 1.11) and MOF (HR 1.05, 95% CI 1.03 to 1.07). The risk of both osteoporosis and MOF was found to increase in a dose-dependent manner. In all, the population-attributable risk was found to be 4.3% (95% CI 2.7% to 5.8%) for osteoporosis and 2.7% (95% CI 1.7% to 3.8%) for MOF. This study de...

RSV vaccination in third trimester associated with significantly reduced infection risk in early months...

...frameworks. From past research, households have been identified as a significant contributor to RSV transmission, but modelling studies have not been conducted on high-income settings yet. The current study’s goal was to model the household-level impact of maternal RSV vaccines in a high-income country. This involved combining Australian census data with a model for RSV transmission, accounting for household and community population mixing, and de...

#VisualAbstract: Metformin for survivors of pediatric brain tumors

.... Metformin was associated with retention of memory and processing speed abilities, as well as a reduction of white matter loss. Evidence Rating Level: 1 (Excellent) It is believed that endogenous neural precursor cells (NPCs) can promote tissue repair in the human brain due to its precursor cell populations. This is an important consideration due to limited self-repair capacities of the brain, such that agents inducing proliferation and different...

Worldwide perspective: a comparison of legislative and public health initiatives in five countries regarding...

...Germany has passed timely and effective legislation that has enacted significant changes in mental health surveillance and firearm restrictions in response to mass shootings. Similarly in Japan, one must pass firearm safety classes as well as a background check that includes psychological evaluation and interviews with family members prior to obtaining a license. Japan also enforces notably strict regulations regarding the type of firearms that ca...

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