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Golimumab effective at preserving insulin production in type 1 diabetes

...ad grade 3-4 neutropenia in the golimumab group. Hypoglycemia was higher in the golimumab group (23%) compared to the placebo (7%). Image: PD ©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc....

Child care providers likely not at increased risk of contracting COVID-19

...US child-care programs. Researchers found that within the context of significant infection mitigation efforts at the child care centers, there was no increased risk of COVID-19 diagnosis amongst the adult child care providers. The strongest predictor of spread to providers was increased rates of background community transmission. These findings suggest that when local virus spread is low and child care programs implement appropriate mitigation eff...

#VisualAbstract: Frontline healthcare workers at greater risk of SARS-CoV-2 infection than the general population

...-19 test. In particular, Black, Asian, and minority ethnic HCPs were significantly more likely to contract the disease than their colleagues. HCPs working in in-patient and nursing home settings, and those with inadequate or re-used personal protective equipment (PPE) due to limited supplies, were at greatest risk of infection acquisition. This study was limited by self-reported data and a lack of random sampling among selected participants. Since...

Multisystem inflammatory syndrome in SARS-CoV-2 infected children has poor outcomes

...hreatening effects of multisystem inflammatory syndrome among SARS-CoV-2 positive children in children who were previously healthy. Image: PD ©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc....

#VisualAbstract: Robotic vs. laparoscopic ventral hernia repair

...) Study Rundown: Surgeries using robotic technologies have increased significantly in the last decade worldwide. In particular, these technologies have become more popularized in general surgery. Despite this however, the longitudinal outcomes and comparative efficacy of these surgeries are not well characterized. The current study was the first randomized controlled trial to compare patient outcomes from laparoscopic ventral hernia repair (LVHR)...

#VisualAbstract: Hospitalization and Mortality among Black Patients and White Patients with Covid-19

...ese findings highlight the existing differences in the clinical course of COVID-19 based on race in patients. Click to read the study in NEJM ©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc....

Naltrexone-bupropion treatment provides a higher response for methamphetamine use disorder

...y’s results to be generalized. Nonetheless, this study’s results are significant, and its findings highlight a potential treatment for methamphetamine use disorder. Click to read the study in NEJM Relevant Reading: Randomized, placebo-controlled trial of bupropion in methamphetamine-dependent participants with less than daily methamphetamine use In-Depth [randomized controlled trial]: This randomized control trial enrolled 403 participants in a mu...

SEP-363856 reduces symptom severity for acute exacerbation of schizophrenia

1. An oral compound, SEP-363856 was shown to significantly reduce the total score of the Positive and Negative Symptom Scale (PANSS) from baseline compare to placebo for patients with an acute exacerbation of schizophrenia. 2. One patient treated with SEP-363856 had sudden cardiac death but had history of coronary artery disease and hypertension. Evidence Rating Level: 1 (Excellent) Study Rundown: Current antipsychotic treatments rely on dopamine...

Liraglutide adjuvant therapy found to increase weight loss in obese adolescents

...1. The combination of liraglutide and lifestyle therapy was shown to significantly reduce body mass index (BMI) standard-deviation score compared to the placebo group. 2. The use of liraglutide as adjuvant therapy was shown to cause a higher frequency of gastrointestinal adverse events. Evidence Rating Level: 1 (Excellent) Study Rundown: Obesity is a chronic and progressive disease with few treatment options for the pediatric patient population. T...

Treating acute migrane headaches with ubrogepant

...experienced an adverse event was slightly higher (16.3%), with the most common complaints being nausea, somnolence, and dry mouth. Image: PD ©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc....

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