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Lomitapide reduces LDL-C by 38% in patients with devastating homozygous familial hypercholesterolemia

...les of the LDL-receptor gene (LDLR). HoFH often presents with the classic findings of xanthelasma palpebrarum, tendon xanthomata, and arcus senilis. Further, the aggressive atherosclerosis associated with HoFH causes significant coronary artery disease, typically requiring numerous surgical interventions including coronary artery bypass grafting (CABG) and angioplasty, and often results in death prior to age 30. Indeed, this grave prognosis highli...

Evolocumab significantly reduces LDL cholesterol in familial hypercholesterolemia patients [TESLA-B and RUTHERFORD-2 studies]

...that lower LDL cholesterol. Recent research efforts have focused on developing novel PCSK9 inhibitors as a means to further lower LDL cholesterol. Evolocumab, an anti-PCSK-9 monoclonal antibody, is one such agent. Results of two randomized-controlled trials were reported today in the Lancet: in the TESLA-B study, patients with homozygous familial hypercholesterolemia treated with evolocumab saw a 30% drop in LDL cholesterol levels at 12 weeks comp...

Soaring rates of peripheral artery disease, now over 200 million cases worldwide

...: This study includes 34 epidemiological studies of 112,027 patients from nineteen different countries (twenty-two from High Income Countries or HICs, twelve from low- or middle-income countries, or LMICs) during the time period between 2000 to 2010. Patients were studied in 5-year age groups (25 to 99 years old) to determine age-specific and sex-specific prevalence rates, Further, 15 PAD risk factors were studied to assess whether these played a...

3D mammography (tomosynthesis) enhances accuracy of breast cancer screening

...in positive predictive value and ability to detect invasive or ductal carcinoma in situ (DCIS) cancers. This study provides an excellent argument for the concurrent use of digital mammography with tomosynthesis in the clincal setting. However, more research will be needed, as well as training by radiologists, due to tomosynthesis being such a novel diagnostic tool. Click to read the study, published today in JAMA Relevant Reading: Comparison of D...

Periodontitis therapy not improving HbA1C levels in type II diabetes patients

...trial]: This large, multicenter study examined 514 individuals, randomized into two groups of 257. At 6 months, mean HbA1c levels in the periodontal therapy group increased 0.17% (SD, 1.0) while that of the control group increased 0.11% (SD, 1.0). Intention-to-treat analyses revealed HbA1c levels at 6 months did not differ significantly between the treatment and control groups (adjusted 6-month treatment effect, −0.05% [95% CI, -0.23% to 0.12%]; p...

Quick Take: Effect of lorcaserin on prevention and remission of type 2 diabetes in...

...weight and the risk of developing diabetes. Lorcaserin is a selective serotonin 2C receptor agonist that suppresses appetite, and has been shown to sustain weight loss. This randomized double-blind placebo-controlled trial aimed to evaluate the long-term effects of lorcaserin on diabetes prevention and remission. Patients with a BMI of 27 kg/m2 or higher were randomly assigned to receive either lorcaserin 10 mg twice daily, or matching placebo. A...

Staph. aureus vaccine does not decrease postoperative infection rates

...ve infection in patients undergoing cardiothoracic surgery with median sternotomy. 2. Among patients with postoperative S. aureus infection, V710 vaccination is associated with increased rates of multiorgan failure and mortality. Study Rundown: The median sternotomy serves as an integral part of many cardiothoracic surgeries including bypass grafts and open valve replacements. The median sternotomy poses the risk of postoperative infection, most c...

Genetic mutations may protect infants born to drug-using mothers

...lying the observed differences from SNPs should also be better delineated. Nonetheless, this study provides a unique avenue or research with possible clinical implications in the future with further research. . Click to read the study, published today in JAMA Relevant Reading: Neonatal Abstinence Syndrome after Methadone or Buprenorphine Exposure In-Depth [prospective study]: This study followed 86 mother-infant dyads, 51 from Tufts Medical Center...

Skilled nursing facility ratings linked to readmission and death rates

...Study Rundown: Hospital reimbursements for inpatient care are increasingly linked to readmission rates within 30 days of discharge. Consequently, there has been an increased focus on the potential role of skilled nursing facilities (SNFs) in providing post-discharge care to help reduce the risk of hospital readmission during this time period. This study aimed to determine whether there was an association between the quality of the SNF, as measured...

Blood transfusions linked with increased risk of adverse cardiac events following percutaneous coronary intervention

...t to understand the relationship between blood transfusions and PCI by examining adverse effects as well as transfusion guidelines. This study revealed variation in transfusion medicine practices for patients undergoing PCI in the United States with more aggressive thresholds for transfusion than others. Most importantly, transfusions in PCI patients were associated with an increased risk of in-hospital adverse events such as myocardial infarction...

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