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2 Minute Medicine Rewind September 22 โ€“ September 29, 2014

...), 1.11 (1.03-1.20), and 1.12 (1.04-1.22) in these trials respectively. In the genetic analysis, researchers analyzed genetic data from 223, 463 individuals and found that on average, each additional rs17238484-G allele decreased LDL levels by 0.06 mmol/L (95% CI 0.05-0.07), increased body weight by 0.30 kg (0.18-0.43), waist circumference by 0.32 cm (0.16-0.47), plasma insulin concentration by 1.62% (0.53-2.72), and plasma glucose concentration b...

Decreased trainee autonomy suggested with in-hospital intensivist coverage

...Moving forward, we need to utilize increased attending presence to enhance the overall educational experience while also continuing to pursue methods to ensure opportunities for housestaff to make autonomous decisions.” In-Depth [cross-sectional study]: This cross-sectional study examined results from an 80-question online survey centered on pediatric resident, medicine-pediatric resident, and critical care fellow educational experiences in relati...

Shared decision making intervention linked to improved value/treatment choice concordance in LVAD destination therapy

...final therapy received at 6 months did not significantly change following the therapy. The main strengths of this study included the evaluation of all patients initially considered for LVAD destination therapy, rather than only those who received the devices. The main limitations of the study included low rate of follow-up in those who declined LVAD therapy, a predominantly white and male population, and the difficulty in generalizing the results...

Validated index scores severity of postsurgical morbidity

...F ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain....

Strict tobacco licensing laws linked to reduced adolescent smoking initiation

...impossible to identify the effects of individual features of TRL policy. Nonetheless, the study is strengthened by its large sample, longitudinal follow-up, and independent grading system. For physicians, these findings highlight the importance of advocating for stronger TRL policy as an effective regulatory tool for reducing adolescent tobacco initiation and use. Click to read the study, published today in Pediatrics Relevant reading: Policy Inte...

Glutamine and antioxidant supplementation provide no benefit for critically-ill patients

...lacebo (p=0.05) and 29.0% v. 25.3% in the antioxidant v. placebo (p=0.48). The overall adjusted odds ratio with glutamine was 1.28 (p=0.05) and 1.09 (p=0.48) with antioxidants. Elevated urea levels (>50 mmol/L) were observed in 13.4% and 4.0% in the glutamine v. no glutamine groups (p<0.001). By Jonathan Liu and Mitalee Patil More from this author: PFO Closure equivalent to medical management in prevention of recurrent stroke, Combo antifungal the...

Lower rates of statin use observed for primary prevention of cardiovascular disease in LGB...

...GB-related pages. There were 1,531 respondents (59.6% women, 90.6% white). Overall, the results showed that among primary intervention individuals, the LGB population had significantly lower rates of statin use (20.8% vs 43.8%, p < 0.001). For secondary intervention however, the use of statins in the LGB population was comparable to the non-LGB population (57.1% vs 57.5%, p = 0.999). These study findings underlie the importance of identifying barr...

[Policy Statement] American Academy of Pediatrics releases updated vaccination schedule

...DVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain. [/tab] [/tabs]...

Meta-analysis suggests novel oral anticoagulants might be safer than warfarin for atrial fibrillation

...s is small, with relative risks close to 1. This raises the question of whether these statistically significant results are truly clinically significant. Overall, the promise of these results is tempered by the absence of a clear path to the clinic. The heterogeneity inherent in combining several agents of different classes in many populations has masked results specific to any one agent or population. So, clinicians currently treating patients wi...

Abusive head trauma results in fewer productive life-years

...bsequent extrapolation makes the results difficult to generalize. However, the paper is the first to attempt to quantify the true burden of AHT disease on the population and found it to be even greater than that of other childhood injuries, including severe burns and more general child maltreatment. This suggests that physicians, advocacy groups, and law enforcement should focus significant prevention efforts on AHT. Click to read the study, publi...

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