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Sitagliptin may reduce acute graft-versus-host disease following allogeneic stem-cell transplantation

...aft-versus-leukemia effects. Only 2 of over 35 patients had acute GVHD at 100 days, and nearly half of the study population remained GVHD-free and relapse-free at 1 year. While gastrointestinal adverse events were fairly common, no toxic effects could be directly attributed to sitagliptin. Overall, sitagliptin appeared to be both safe and highly efficacious in lowering the incidence of acute GVHD after HSCT. Larger, randomized controlled trials sh...

Vaginal misoprostol improves ease of IUD insertion

...2 (Good) Study Rundown: This study found that vaginal administration of a 400μg misoprostol tablet four hours before IUD insertion reduces the difficulty of and pain associated with IUD placement in nulligravid women. Findings suggest that this dosage, timing and route of misoprostol administration facilitate IUD insertions in nulligravidas and might be considered for standard practice. Strengths of this study include a double-blind, RCT study des...

Repeat opioid overdose linked to continued use of high-dose prescriptions

...At 60 days before the initial overdose, 46% of patients had a high dose (>100 mg MED), 22% had a moderate dose (50 to <100 mg MED) and 33% had a low dose (>0 to <50 mg MED) opioid prescription. At 31-90 days after the initial overdose, these percentages changed to 34% high dose, 17% moderate dose, and 37% low dose prescription, plus 12% had no opioid prescription. These numbers did not change significantly during the remainder of the follow-up per...

Daily aspirin may not improve overall prostate cancer mortality

...th non-metastatic prostate cancer. This trial prospectively followed over 8000 men with non-metastatic prostate cancer currently on (pre-diagnosis) or starting (post-diagnosis) aspirin therapy. After a mean follow-up of 9 and 6 years for pre- and post-diagnosis respectively, the authors found that aspirin use did not have a statistically significant effect on PCSM, regardless of frequency or level of dosing. However, sub-group analysis demonstrate...

Hydroxychloroquine shows no greater effectiveness than placebo for hand osteoarthritis pain

...matic and radiographic hand osteoarthritis were randomly assigned to HCQ (200 to 400 mg) or placebo for 12 months along with usual care. At 6 months, HCQ did not show any greater effectiveness for the primary end point of average hand pain for the 2-week duration prior to data collection. There was also no significant difference between HCQ and placebo for secondary end points including function, grip strength, radiographic structural damage, and...

Aspirin vs warfarin in atherosclerotic intracranial stenosis [Classics Series]

...ge compared to the aspirin group. Original Date of Publication: March 31, 2005 Study Rundown: This trial randomized patients who were recently diagnosed with a stroke due to intracranial atherosclerotic stenosis to prophylactic treatment with either high-dose aspirin or warfarin. The trial was stopped early because the warfarin treatment group had a much higher incidence of major hemorrhages compared to the aspirin treatment group. There was no si...

Vitamin D supplementation not associated with lower risk of tuberculosis in school-age children

...the risk of both tuberculosis infection and tuberculosis disease. Nearly 9000 children participated in the study, and the percentage who experienced a conversion to a positive QuantiFERON-TB test (QFT) result at the 3-year follow-up was similar between groups. Additionally, tuberculosis disease and acute respiratory infection were diagnosed at similar rates in both groups throughout the study. No adverse events related to the treatment regimen we...

Co-prescription of clarithryomycin with direct oral anticoagulants associated with increased bleed risk.

...ohort study involved 24,943 older adults (M [SD] age = 77.6 [7.2] years, 51.0% women) living in Ontario, Canada, taking DOACs, and assessed whether co-prescription of either clarithromycin or azithromycin, macrolide antibiotics commonly prescribed for respiratory infections and known to affect CYP3A4 complexes, were associated with an increased risk of hemorrhage requiring hospitalization. The primary outcome was hospitalization for major hemorrha...

#VisualAbstract: Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease

...the risk of both tuberculosis infection and tuberculosis disease. Nearly 9000 children participated in the study, and the percentage who experienced a conversion to a positive QuantiFERON-TB test (QFT) result at the 3-year follow-up was similar between groups. Additionally, tuberculosis disease and acute respiratory infection were diagnosed at similar rates in both groups throughout the study. No adverse events related to the treatment regimen we...

2 Minute Medicine Rewind June 15, 2020

...ohort study involved 24,943 older adults (M [SD] age = 77.6 [7.2] years, 51.0% women) living in Ontario, Canada, taking DOACs, and assessed whether co-prescription of either clarithromycin or azithromycin, macrolide antibiotics commonly prescribed for respiratory infections and known to affect CYP3A4 complexes, were associated with an increased risk of hemorrhage requiring hospitalization. The primary outcome was hospitalization for major hemorrha...

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